{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:09:08Z","timestamp":1773047348484,"version":"3.50.1"},"reference-count":69,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec>\n            <jats:title>Purpose of review<\/jats:title>\n            <jats:p>Neonatal blistering diseases are rare yet potentially fatal. Therefore, it is crucial for clinicians to know its broad range of differential diagnoses. This review discusses the recent literature on the causes and the most appropriate clinical approach to neonatal blistering diseases.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Recent findings<\/jats:title>\n            <jats:p>Neonatal infections are the commonest causes for neonatal blistering. On the other hand, autoimmune blistering diseases are extremely rare with the literature limited to case reports and one systematic review only. Inherited genodermatoses are also rare, with recent developments in epidermolysis bullosa classification.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Summary<\/jats:title>\n            <jats:p>In conclusion, as neonatal infections are the commonest cause for blistering, any neonate with blistering should have their blister fluid investigated for infection, while an antimicrobial should be initiated early. Autoimmune blistering diseases should be considered in neonates with a maternal history of autoimmune blistering disease. Although pemphigus and bullous pemphigoid have overall good prognoses, linear IgA bullous dermatoses has a poor prognosis and requires aggressive treatment. Inherited genodermatoses should be suspected when there is a family history of genodermatoses or consanguinity. In this case, the clinician should not hesitate to seek dermatology advice, perform a skin biopsy and consider genetic testing.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/mop.0000000000000381","type":"journal-article","created":{"date-parts":[[2016,6,11]],"date-time":"2016-06-11T16:30:01Z","timestamp":1465662601000},"page":"500-506","source":"Crossref","is-referenced-by-count":14,"title":["Blistering diseases in neonates"],"prefix":"10.1097","volume":"28","author":[{"given":"Cathy Y.","family":"Zhao","sequence":"first","affiliation":[{"name":"Dermatology, St George Hospital"},{"name":"Medicine, University of New South Wales, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dedee F.","family":"Murrell","sequence":"additional","affiliation":[{"name":"Dermatology, St George Hospital"},{"name":"Medicine, University of New South Wales, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20230918","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/01.mop.0000171320.91677.55","article-title":"Neonatal cutaneous fungal infections","volume":"17","author":"Smolinski","year":"2005","journal-title":"Curr Opin Pediatr"},{"key":"R2-20230918","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/320403","article-title":"Diagnostic pitfalls in newborns and babies with blisters and erosions","volume":"2009","author":"Nischler","year":"2009","journal-title":"Dermatol Res Pract"},{"key":"R3-20230918","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1542\/peds.108.2.223","article-title":"Natural history of neonatal herpes simplex virus infections in the acyclovir era","volume":"108","author":"Kimberlin","year":"2001","journal-title":"Pediatrics"},{"key":"R4-20230918","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1525-1470.2006.00254.x","article-title":"Herpetic infection in epidermolysis bullosa","volume":"23","author":"Rubin","year":"2006","journal-title":"Pediatr Dermatol"},{"key":"R5-20230918","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1111\/pde.12766","article-title":"\u201cEB, or Not EB?\u201d Neonatal desquamative impetigo in a degloving pattern","volume":"33","author":"Nguyen","year":"2016","journal-title":"Pediatr Dermatol"},{"key":"R6-20230918","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/infdis\/158.1.109","article-title":"Changing presentation of herpes simplex virus infection in neonates","volume":"158","author":"Whitley","year":"1988","journal-title":"J Infect Dis"},{"key":"R7-20230918","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1001\/jama.289.2.203","article-title":"Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant","volume":"289","author":"Brown","year":"2003","journal-title":"JAMA"},{"key":"R8-20230918","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.clp.2014.10.005","article-title":"Neonatal herpes simplex virus infection: epidemiology and treatment","volume":"42","author":"James","year":"2015","journal-title":"Clin Perinatol"},{"key":"R9-20230918","first-page":"375","article-title":"Herpes simplex viruses","author":"Whitley","year":"2004","journal-title":"Clinical virology"},{"key":"R10-20230918","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1542\/peds.108.2.230","article-title":"Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections","volume":"108","author":"Kimberlin","year":"2001","journal-title":"Pediatrics"},{"key":"R11-20230918","doi-asserted-by":"crossref","DOI":"10.1111\/pde.12859","article-title":"Neonatal autoimmune blistering disease: a systematic review","author":"Zhao","year":"2016","journal-title":"Pediatr Dermatol"},{"key":"R12-20230918","first-page":"169","article-title":"A congenital acantholytic bullous eruption in the newborn infant of a pemphigous mother","volume":"12","author":"Ruocco","year":"1975","journal-title":"Ital Gen Rev Dermatol"},{"key":"R13-20230918","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1001\/archderm.1979.04010030024009","article-title":"In vivo bound pemphigus antibodies in a stillborn infant. 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