{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:52:09Z","timestamp":1781081529128,"version":"3.54.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n            <jats:title>Purpose of review<\/jats:title>\n            <jats:p>Over the last 2 years, algorithms for the optimal management of status epilepticus have changed, as the medical community has recognized the need to terminate seizures in status in a timely manner. Recent research has evaluated the different choices of benzodiazepine and has given consideration to second-line treatment options.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Recent findings<\/jats:title>\n            <jats:p>There has been a move to examine alternatives to phenytoin (such as levetiracetam and lacosamide) as second-line agents. Valproate should be used cautiously in view of the potential side effects. Three ongoing trials [Established Staus Epilepticus Treatment Trial (ESETT), Convulsive Status Epilepticus Paediatric Trial (ConSEPT), and emergency treatment with levetiracetam or phenytoin in status epilepticus in children (EcLiPSE)] are comparing the efficacy of levetiracetam and phenytoin.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Summary<\/jats:title>\n            <jats:p>Benzodiazepines remain the first-line agent of choice, although there is ongoing discussion about the mode of administration and the best drug to choose. The results of ESETT, ConSEPT, and EcLiPSE will affect our future management of status, as we give consideration to levetiracetam as an alternative to phenytoin. Other medications such as lacosamide may emerge in future algorithms too.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/mop.0000000000000616","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T22:25:03Z","timestamp":1519338303000},"page":"359-363","source":"Crossref","is-referenced-by-count":18,"title":["An update in the initial management of paediatric status epilepticus"],"prefix":"10.1097","volume":"30","author":[{"given":"Ben","family":"Lawton","sequence":"first","affiliation":[{"name":"Emergency Department, Lady Cilento Children's Hospital, South Brisbane"},{"name":"Emergency Department, School of Medicine, University of Queensland, St Lucia"},{"name":"Emergency Department, Logan Hospital, Meadowbrook, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Davis","sequence":"additional","affiliation":[{"name":"Emergency Department, Royal London Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Emergency Department, Lady Cilento Children's Hospital, South Brisbane"},{"name":"Emergency Department, School of Medicine, University of Queensland, St Lucia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Tagg","sequence":"additional","affiliation":[{"name":"Emergency Department, Footscray Hospital, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-20230918","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0140-6736(06)69043-0","article-title":"Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based study","volume":"368","author":"Chin","year":"2006","journal-title":"Lancet"},{"key":"R4-20230918","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/epi.13121","article-title":"A definition and classification of status epilepticus \u2013 report of the ILAE Task Force on Classification of Status Epilepticus","volume":"56","author":"Trinka","year":"2015","journal-title":"Epilepsia"},{"key":"R5-20230918","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3390\/jcm5040047","article-title":"Management of status epilepticus in children","volume":"5","author":"Smith","year":"2016","journal-title":"J Clin Med"},{"key":"R6-20230918","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1528-1157.1970.tb03880.x","article-title":"Convulsive status epilepticus in infants and children. 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