{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:01:42Z","timestamp":1790175702197,"version":"4.1.0"},"reference-count":102,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n            <jats:title>Purpose of review<\/jats:title>\n            <jats:p>To summarize advances in the genetics underlying variation in normal pubertal timing, precocious puberty, and delayed puberty, and to discuss mechanisms by which genes may regulate pubertal timing.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Recent findings<\/jats:title>\n            <jats:p>Genome-wide association studies have identified hundreds of loci that affect pubertal timing in the general population in both sexes and across ethnic groups. Single genes have been implicated in both precocious and delayed puberty. Potential mechanisms for how these genetic loci influence pubertal timing may include effects on the development and function of the GnRH neuronal network and the responsiveness of end-organs.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Summary<\/jats:title>\n            <jats:p>There has been significant progress in identifying genetic loci that affect normal pubertal timing, and the first single-gene causes of precocious and delayed puberty are being described. How these genes influence pubertal timing remains to be determined.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/mop.0000000000000642","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T19:27:21Z","timestamp":1526498841000},"page":"532-540","source":"Crossref","is-referenced-by-count":49,"title":["Genetics of pubertal timing"],"prefix":"10.1097","volume":"30","author":[{"given":"Jia","family":"Zhu","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Boston Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temitope O.","family":"Kusa","sequence":"additional","affiliation":[{"name":"Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee-Ming","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Boston Children's Hospital"},{"name":"Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20240108","doi-asserted-by":"crossref","first-page":"11208","DOI":"10.1038\/srep11208","article-title":"Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study","volume":"5","author":"Day","year":"2015","journal-title":"Sci Rep"},{"key":"R2-20240108","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/ng.3841","article-title":"Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk","volume":"49","author":"Day","year":"2017","journal-title":"Nat 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