{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:40:46Z","timestamp":1790286046506,"version":"4.1.0"},"reference-count":69,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose of review<\/jats:title>\n                    <jats:p>The mechanisms underlying the overlap of, and relationship between, atopy and immunodeficiency are just beginning to be recognized, through the identification of novel genetic conditions and the reexamination of well known primary immunodeficiencies. The present review seeks both to frame the topic and to highlight the most recent literature combining allergy in the context of immunodeficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent findings<\/jats:title>\n                    <jats:p>The true prevalence of atopic disorders in the setting of primary immunodeficiency as a whole is difficult to pinpoint, however there have been recent attempts to measure prevalence. Individual immunodeficiency disorders have been more carefully dissected for atopic disease and the mechanisms underlying the atopic phenotypic, whereas several newly described immune deficiencies because of single gene mutations are highly associated with atopic phenotypes. Finally, a number of novel genetic conditions with atopy being the primary feature, even in the absence of overt immune deficiency, have been described, providing instrumental clues into the diagnostic dilemmas these syndromes create.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Defining and examining diseases with primary features of atopy and infection allow for a better understanding of the interplay between the two in rare disease, and hopefully sheds light on fundamental pathways involved in atopy and host defense in the general population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/mop.0000000000000697","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T18:10:09Z","timestamp":1537985409000},"page":"848-854","source":"Crossref","is-referenced-by-count":26,"title":["The overlap between allergy and immunodeficiency"],"prefix":"10.1097","volume":"30","author":[{"given":"Kristin","family":"Sokol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Milner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230918","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1084\/jem.20172306","article-title":"Primary atopic disorders","volume":"215","author":"Lyons","year":"2018","journal-title":"J Exp Med"},{"issue":"(Suppl 1)","key":"R2-20230918","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1007\/s10875-007-9159-y","article-title":"Autoimmunity in severe combined immunodeficiency (SCID): lessons from patients and experimental models","volume":"28","author":"Milner","year":"2008","journal-title":"J Clin Immunol"},{"key":"R3-20230918","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.jaci.2008.09.037","article-title":"Omenn syndrome: inflammation in leaky severe combined immunodeficiency","volume":"122","author":"Villa","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"R4-20230918","first-page":"1","article-title":"Is recurrent respiratory infection associated with allergic respiratory disease?","author":"de Oliveira","year":"2018","journal-title":"J Asthma"},{"key":"R5-20230918","doi-asserted-by":"crossref","first-page":"e0192330","DOI":"10.1371\/journal.pone.0192330","article-title":"Acute and chronic rhinosinusitis and allergic rhinitis in relation to comorbidity, ethnicity and environment","volume":"13","author":"Hoffmans","year":"2018","journal-title":"PLoS One"},{"key":"R6-20230918","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s12016-016-8548-5","article-title":"Bacterial and viral infections in atopic dermatitis: a comprehensive review","volume":"51","author":"Ong","year":"2016","journal-title":"Clin Rev Allergy Immunol"},{"key":"R7-20230918","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jaad.2017.09.052","article-title":"Risk of infection in patients with atopic dermatitis treated with dupilumab: a meta-analysis of randomized controlled trials","volume":"78","author":"Fleming","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"R8-20230918","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.anai.2017.07.019","article-title":"Filaggrin mutations and Molluscum contagiosum skin infection in patients with atopic dermatitis","volume":"119","author":"Manti","year":"2017","journal-title":"Ann Allergy Asthma Immunol"},{"key":"R9-20230918","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.immuni.2015.03.014","article-title":"Dysbiosis and Staphylococcus aureus colonization drives inflammation in atopic Dermatitis","volume":"42","author":"Kobayashi","year":"2015","journal-title":"Immunity"},{"key":"R10-20230918","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aah4680","article-title":"Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis","volume":"9","author":"Nakatsuji","year":"2017","journal-title":"Sci Transl Med"},{"key":"R11-20230918","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.120608","article-title":"First-in-human topical microbiome transplantation with Roseomonas mucosa for atopic dermatitis","volume":"3","author":"Myles","year":"2018","journal-title":"JCI Insight"},{"key":"R12-20230918","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jaci.2014.09.024","article-title":"Food allergy in patients with primary immunodeficiency diseases: prevalence within the US Immunodeficiency Network (USIDNET)","volume":"135","author":"Tuano","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"R13-20230918","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.anai.2017.09.075","article-title":"Allergic disease in patients with common variable immunodeficiency at a tertiary care referral center","volume":"120","author":"Bjelac","year":"2018","journal-title":"Ann Allergy Asthma Immunol"},{"key":"R14-20230918","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.jaci.2013.05.040","article-title":"Elevated IgE and atopy in patients treated for early-onset ADA-SCID","volume":"132","author":"Lawrence","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"R15-20230918","doi-asserted-by":"crossref","first-page":"e2786","DOI":"10.5812\/ijp.2786","article-title":"Atopic manifestations: dermatitis, allergic rhinitis and asthma in patients with hypogammaglobulinemia","volume":"25","author":"Dadkhah","year":"2015","journal-title":"Iran J Pediatr"},{"key":"R16-20230918","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s10875-008-9229-9","article-title":"IgA deficiency: correlation between clinical and immunological phenotypes","volume":"29","author":"Aghamohammadi","year":"2009","journal-title":"J Clin Immunol"},{"issue":"(Suppl 1)","key":"R17-20230918","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1007\/s10875-007-9163-2","article-title":"Autoimmunity in IgA deficiency: revisiting the role of IgA as a silent housekeeper","volume":"28","author":"Jacob","year":"2008","journal-title":"J Clin Immunol"},{"key":"R18-20230918","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.clim.2009.05.014","article-title":"Selective IgA deficiency in early life: association to infections and allergic diseases during childhood","volume":"133","author":"Janzi","year":"2009","journal-title":"Clin Immunol"},{"key":"R19-20230918","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1525-1470.2011.01409.x","article-title":"Skin manifestations in primary immunodeficient children","volume":"28","author":"Al-Herz","year":"2011","journal-title":"Pediatr Dermatol"},{"key":"R20-20230918","first-page":"658279","article-title":"An overlapping syndrome of allergy and immune deficiency in children","volume":"2012","author":"Szczawinska-Poplonyk","year":"2012","journal-title":"J Allergy (Cairo)"},{"key":"R21-20230918","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s00431-005-1745-5","article-title":"Inherited defects in the interferon-gamma receptor or interleukin-12 signalling pathways are not sufficient to cause allergic disease in children","volume":"164","author":"Wood","year":"2005","journal-title":"Eur J Pediatr"},{"key":"R22-20230918","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.clim.2007.02.001","article-title":"Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome","volume":"124","author":"Adriani","year":"2007","journal-title":"Clin Immunol"},{"key":"R23-20230918","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1172\/JCI29539","article-title":"Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis","volume":"117","author":"Humblet-Baron","year":"2007","journal-title":"J Clin Invest"},{"key":"R24-20230918","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1084\/jem.20061338","article-title":"The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells","volume":"204","author":"Maillard","year":"2007","journal-title":"J Exp Med"},{"key":"R25-20230918","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1172\/JCI85129","article-title":"FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy","volume":"126","author":"Lexmond","year":"2016","journal-title":"J Clin Invest"},{"key":"R26-20230918","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/intimm\/dxg148","article-title":"Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells","volume":"15","author":"Pivniouk","year":"2003","journal-title":"Int Immunol"},{"key":"R27-20230918","doi-asserted-by":"crossref","first-page":"14816","DOI":"10.1038\/ncomms14816","article-title":"Loss of the Arp2\/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease","volume":"8","author":"Kahr","year":"2017","journal-title":"Nat Commun"},{"key":"R28-20230918","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jaci.2016.09.061","article-title":"Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency","volume":"140","author":"Kuijpers","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"R29-20230918","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.4049\/jimmunol.1700460","article-title":"Disruption of thrombocyte and T lymphocyte development by a mutation in ARPC1B","volume":"199","author":"Somech","year":"2017","journal-title":"J Immunol"},{"key":"R30-20230918","doi-asserted-by":"crossref","first-page":"8952","DOI":"10.1038\/s41598-017-08357-4","article-title":"Arp2\/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR(+) endosome trafficking","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci Rep"},{"key":"R31-20230918","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/all.12416","article-title":"Atopic dermatitis, STAT3- and DOCK8-hyper-IgE syndromes differ in IgE-based sensitization pattern","volume":"69","author":"Boos","year":"2014","journal-title":"Allergy"},{"key":"R32-20230918","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.jaci.2013.08.045","article-title":"Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation","volume":"132","author":"Siegel","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"R33-20230918","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jaci.2015.11.024","article-title":"Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis","volume":"138","author":"Hox","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"R34-20230918","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1056\/NEJMoa0905506","article-title":"Combined immunodeficiency associated with DOCK8 mutations","volume":"361","author":"Zhang","year":"2009","journal-title":"New Engl J Med"},{"key":"R35-20230918","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1172\/JCI85774","article-title":"A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton","volume":"126","author":"Janssen","year":"2016","journal-title":"J Clin Invest"},{"key":"R36-20230918","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/ni.2305","article-title":"DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation","volume":"13","author":"Jabara","year":"2012","journal-title":"Nat Immunol"},{"key":"R37-20230918","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.jaci.2016.04.023","article-title":"Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation","volume":"138","author":"Keles","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"R38-20230918","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.clim.2017.08.020","article-title":"DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells","volume":"183","author":"Massaad","year":"2017","journal-title":"Clin Immunol"},{"key":"R39-20230918","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jaci.2015.07.047","article-title":"Neonatal-onset T(-)B(-)NK(+) severe combined immunodeficiency and neutropenia caused by mutated phosphoglucomutase 3","volume":"137","author":"Bernth-Jensen","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"R40-20230918","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.jaci.2014.02.025","article-title":"Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels","volume":"133","author":"Sassi","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"R41-20230918","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ajhg.2014.05.007","article-title":"PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia","volume":"95","author":"Stray-Pedersen","year":"2014","journal-title":"Am J Hum Genet"},{"key":"R42-20230918","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.jaci.2014.02.013","article-title":"Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment","volume":"133","author":"Zhang","year":"2014","journal-title":"J Allergy ClinI Immunol"},{"key":"R43-20230918","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molimm.2017.06.248","article-title":"A founder mutation underlies a severe form of phosphoglutamase 3 (PGM3) deficiency in Tunisian patients","volume":"90","author":"Ben-Khemis","year":"2017","journal-title":"Mol Immunol"},{"key":"R44-20230918","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat4956","article-title":"A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity","volume":"3","author":"Beziat","year":"2018","journal-title":"Sci Immunol"},{"key":"R45-20230918","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat4941","article-title":"ZNF341 controls STAT3 expression and thereby immunocompetence","volume":"3","author":"Frey-Jakobs","year":"2018","journal-title":"Sci Immunol"},{"key":"R46-20230918","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/cr.2010.168","article-title":"Regulation of NF-kappaB signaling by caspases and MALT1 paracaspase","volume":"21","author":"Staal","year":"2011","journal-title":"Cell Res"},{"key":"R47-20230918","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/ng.3898","article-title":"Germline hypomorphic CARD11 mutations in severe atopic disease","volume":"49","author":"Ma","year":"2017","journal-title":"Nat Genet"},{"key":"R48-20230918","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.jaci.2017.06.047","article-title":"Combined immunodeficiency and atopy caused by a dominant negative mutation in caspase activation and recruitment domain family member 11 (CARD11)","volume":"141","author":"Dadi","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"R49-20230918","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ni.2005","article-title":"The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2","volume":"12","author":"Delgoffe","year":"2011","journal-title":"Nat Immunol"},{"key":"R50-20230918","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.celrep.2012.02.007","article-title":"PI3K-Akt-mTORC1-S6K1\/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORgamma","volume":"1","author":"Kurebayashi","year":"2012","journal-title":"Cell Rep"},{"key":"R51-20230918","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.immuni.2010.06.002","article-title":"Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways","volume":"32","author":"Lee","year":"2010","journal-title":"Immunity"},{"key":"R52-20230918","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.immuni.2016.08.017","article-title":"mTORC1 and mTORC2 kinase signaling and glucose metabolism drive follicular helper T cell differentiation","volume":"45","author":"Zeng","year":"2016","journal-title":"Immunity"},{"key":"R53-20230918","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/ng.2438","article-title":"Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population","volume":"44","author":"Hirota","year":"2012","journal-title":"Nat Genet"},{"key":"R54-20230918","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1365-3016.2010.01173.x","article-title":"Glutamine-enriched enteral nutrition in very low birthweight infants and allergic and infectious diseases at 6 years of age","volume":"25","author":"van Zwol","year":"2011","journal-title":"Paediatr Perinat Epidemiol"},{"key":"R55-20230918","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.jaci.2016.12.957","article-title":"JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome","volume":"139","author":"Del Bel","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"R56-20230918","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3389\/fimmu.2012.00234","article-title":"The STAT5b pathway defect and autoimmunity","volume":"3","author":"Kanai","year":"2012","journal-title":"Front Immunol"},{"key":"R57-20230918","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1182\/blood-2016-09-737817","article-title":"Somatic STAT5b gain-of-function mutations in early onset nonclonal eosinophilia, urticaria, dermatitis, and diarrhea","volume":"129","author":"Ma","year":"2017","journal-title":"Blood"},{"key":"R58-20230918","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1056\/NEJMoa1500611","article-title":"Vibratory urticaria associated with a missense variant in ADGRE2","volume":"374","author":"Boyden","year":"2016","journal-title":"N Engl J Med"},{"key":"R59-20230918","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1056\/NEJMoa1102140","article-title":"Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions","volume":"366","author":"Ombrello","year":"2012","journal-title":"N Engl J Med"},{"key":"R60-20230918","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.jaci.2009.09.035","article-title":"Familial atypical cold urticaria: description of a new hereditary disease","volume":"124","author":"Gandhi","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"R61-20230918","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1056\/NEJMoa055695","article-title":"Aneurysm syndromes caused by mutations in the TGF-beta receptor","volume":"355","author":"Loeys","year":"2006","journal-title":"N Engl J Med"},{"key":"R62-20230918","doi-asserted-by":"crossref","first-page":"195ra94","DOI":"10.1126\/scitranslmed.3006448","article-title":"TGFbeta receptor mutations impose a strong predisposition for human allergic disease","volume":"5","author":"Frischmeyer-Guerrerio","year":"2013","journal-title":"Sci Transl Med"},{"key":"R63-20230918","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ajhg.2010.07.005","article-title":"Loss of corneodesmosin leads to severe skin barrier defect, pruritus, and atopy: unraveling the peeling skin disease","volume":"87","author":"Oji","year":"2010","journal-title":"Am J Hum Genet"},{"key":"R64-20230918","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.jaci.2015.05.002","article-title":"Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin","volume":"136","author":"McAleer","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"R65-20230918","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/ng.2739","article-title":"Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting","volume":"45","author":"Samuelov","year":"2013","journal-title":"Nat Genet"},{"key":"R66-20230918","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/75977","article-title":"Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome","volume":"25","author":"Chavanas","year":"2000","journal-title":"Nat Genet"},{"key":"R67-20230918","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/ng2020","article-title":"Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema","volume":"39","author":"Sandilands","year":"2007","journal-title":"Nat Genet"},{"key":"R68-20230918","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJMra1011040","article-title":"Filaggrin mutations associated with skin and allergic diseases","volume":"365","author":"Irvine","year":"2011","journal-title":"N Engl J Med"},{"key":"R69-20230918","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/ng.3696","article-title":"Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number","volume":"48","author":"Lyons","year":"2016","journal-title":"Nat Genet"}],"container-title":["Current Opinion in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00008480-201812000-00022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T22:25:30Z","timestamp":1694989530000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00008480-201812000-00022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":69,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1097\/mop.0000000000000697","relation":{},"ISSN":["1040-8703","1531-698X"],"issn-type":[{"value":"1040-8703","type":"print"},{"value":"1531-698X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]}}}