{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:08:24Z","timestamp":1778155704960,"version":"3.51.4"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n            <jats:title>Purpose of review<\/jats:title>\n            <jats:p>To provide an update on the consequences of severe acute respiratory syndrome (SARS)-CoV-2 infection on the health and perinatal outcomes of pregnant women and their infants.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Recent findings<\/jats:title>\n            <jats:p>The severity of SARS-CoV-2 infection is greater in pregnant compared to nonpregnant women as measured by rates of admission to intensive care units, mechanical ventilation, mortality, and morbidities including myocardial infarction, venous thromboembolic and other thrombotic events, preeclampsia, preterm labor, and preterm birth. The risk of transmission from mother-to-infant is relatively low (1.5\u20135%) as quantitated by neonatal SARS-CoV-2 testing. Infants appear to be at higher risk of testing positive for SARS-CoV-2 if the mother has tested positive within 1 week of delivery or is herself symptomatic at the time of maternity admission. The rate of positivity is not higher in infants who room in with the mother compared to infants who are initially separated and cared for in a SARS-CoV-2-free environment. Infants who test positive in the hospital have no or mild signs of disease, most of which may be attributable to prematurity, and rarely require readmission for clinical signs consistent with COVID-19.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Summary<\/jats:title>\n            <jats:p>Pregnant women should take precautions to avoid infection with SARS-CoV-2. Infants born to mothers who test positive for SARS-CoV-2 can receive normal neonatal care in-hospital with their mothers if mother and staff adhere to recommended infection control practices.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/mop.0000000000001004","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T02:09:38Z","timestamp":1614391778000},"page":"181-187","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Consequences of the SARS-CoV-2 pandemic in the perinatal period"],"prefix":"10.1097","volume":"33","author":[{"given":"Mark L.","family":"Hudak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"R1-20250730","first-page":"1","article-title":"COVID-19: neonatal-perinatal perspectives","volume":"8","author":"Barrero-Castillero","year":"2020","journal-title":"J Perinatol"},{"key":"R2-20250730","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1056\/NEJMc2009316","article-title":"Universal screening for SARS-CoV-2 in women admitted for delivery","volume":"382","author":"Sutton","year":"2020","journal-title":"N Engl J Med"},{"key":"R3-20250730","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/AOG.0000000000003983","article-title":"Clinical implications of universal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) testing in pregnancy","volume":"136","author":"Miller","year":"2020","journal-title":"Obstet Gynecol"},{"key":"R4-20250730","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/AOG.0000000000003987","article-title":"Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) universal testing experience on a Los Angeles labor and delivery unit","volume":"136","author":"Naqvi","year":"2020","journal-title":"Obstet Gynecol"},{"key":"R5-20250730","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1001\/jama.2020.11370","article-title":"Associations between built environment, neighborhood socioeconomic status, and SARS-CoV-2 infection among pregnant women in New York City","volume":"324","author":"Emeruwa","year":"2020","journal-title":"JAMA"},{"key":"R6-20250730","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.15585\/mmwr.mm6944e3","article-title":"Update: characteristics of symptomatic women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status - United States, January 22-October 3, 2020","volume":"69","author":"Zambrano","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"R7-20250730","first-page":"e209241","article-title":"Clinical characteristics and outcomes of hospitalized women giving birth with and without COVID-19","author":"Jering","year":"2021","journal-title":"JAMA Intern Med"},{"key":"R8-20250730","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.15585\/mmwr.mm6944e2","article-title":"Birth and infant outcomes following laboratory-confirmed SARS-CoV-2 infection in Pregnancy- SET-NET, 16 Jurisdictions, March 29-October 14, 2020","volume":"69","author":"Woodworth","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"R9-20250730","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1001\/jama.2020.12746","article-title":"Change in the incidence of stillbirth and preterm delivery during the COVID-19 pandemic","volume":"324","author":"Khalil","year":"2020","journal-title":"JAMA"},{"key":"R10-20250730","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1097\/AOG.0000000000004178","article-title":"Clinical presentation of Coronavirus Disease 2019 (COVID-19) in pregnant and recently pregnant people","volume":"136","author":"Afshar","year":"2020","journal-title":"Obstet Gynecol"},{"key":"R11-20250730","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1097\/AOG.0000000000004103","article-title":"Corticosteroids in the management of pregnant patients with Coronavirus Disease (COVID-19)","volume":"136","author":"Saad","year":"2020","journal-title":"Obstet Gynecol"},{"key":"R12-20250730","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/aogs.13870","article-title":"Classification system and case definition for SARS-CoV-2 infection in pregnant women, fetuses, and neonates","volume":"99","author":"Shah","year":"2020","journal-title":"Acta Obstet Gynecol Scand"},{"key":"R13-20250730","first-page":"1848","article-title":"Antibodies in infants born to mothers with COVID-19 pneumonia","volume":"323","author":"Zeng","year":"2020","journal-title":"JAMA"},{"key":"R14-20250730","first-page":"1846","article-title":"Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn","volume":"323","author":"Dong","year":"2020","journal-title":"JAMA"},{"key":"R15-20250730","first-page":"1788","article-title":"Can SARS-CoV-2 Infection be acquired in utero? 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