{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:49:09Z","timestamp":1790858949672,"version":"4.1.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n            <jats:title>Purpose of review<\/jats:title>\n            <jats:p>Children with systemic malignancies can present with concomitant dermatological manifestations. Cutaneous findings can occur before, during or after diagnosis. Recognizing these features can aid in diagnosis, inform prognosis, and help determine appropriate treatment. Following a review of the literature published over the past two years, we provide an update on cutaneous signs of pediatric systemic malignancies, concentrating on; leukemia cutis, lymphoma cutis, neuroblastoma, sarcomas, Langerhans cell histiocytosis and paraneoplastic syndromes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Recent findings<\/jats:title>\n            <jats:p>Authors highlight the persistently heterogeneous features of cutaneous manifestations of systemic malignancy. Findings are often nonspecific, and a definitive diagnosis requires skin biopsy with immunophenotyping. Several studies describe dermoscopy features, demonstrating this as a useful tool in clinical evaluation. Genetic mutations underlying the pathogenesis of disease continue to be elucidated. Further, advances in medical treatment led to improved prognosis in many systemic malignancies, with early and aggressive treatment heralding better outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Summary<\/jats:title>\n            <jats:p>Comprehensive cutaneous evaluation alongside thorough clinical history and review of systems remains of paramount importance as dermatological manifestations of systemic malignancy are notoriously variable with a shared feature of often appearing benign but persisting despite usual treatment. Urgent referral to dermatology is recommended when suspicion for any cutaneous presentation of malignancy arises.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/mop.0000000000001152","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T04:02:17Z","timestamp":1657080137000},"page":"367-373","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Pearls and updates: cutaneous signs of systemic malignancy"],"prefix":"10.1097","volume":"34","author":[{"given":"Gabriella M.","family":"Paquette","sequence":"first","affiliation":[{"name":"UMass Chan Medical School, Worcester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Cotter","sequence":"additional","affiliation":[{"name":"Dermatology Section, Division of Immunology, Boston Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer T.","family":"Huang","sequence":"additional","affiliation":[{"name":"Dermatology Section, Division of Immunology, Boston Children's Hospital"},{"name":"Department of Dermatology, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"R2-20250730","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/pde.13864","article-title":"Pediatric leukemia cutis: a case series","volume":"36","author":"Andriescu","year":"2019","journal-title":"Pediatr Dermatol"},{"key":"R3-20250730","first-page":"360","article-title":"Extramedullary manifestations in acute lymphoblastic leukemia in children: a systematic review and guideline-based approach of treatment","volume":"10","author":"Shahriari","year":"2020","journal-title":"Am J Blood Res"},{"key":"R5-20250730","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/MOP.0000000000000855","article-title":"Pediatric acute myeloid leukemia: updates on biology, risk stratification, and therapy","volume":"32","author":"Elgarten","year":"2020","journal-title":"Curr Opin Pediatr"},{"key":"R6-20250730","first-page":"411","article-title":"Leukemia cutis and other dermatological findings in pediatric patients with acute myeloid leukemia","volume":"78","author":"Godinez-Chaparro","year":"2021","journal-title":"Bol Med Hosp Infant Mex"},{"key":"R7-20250730","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4103\/ijd.IJD_534_19","article-title":"Dermoscopic features of Leukemia Cutis-case series","volume":"66","author":"Slawinska","year":"2021","journal-title":"Indian J Dermatol"},{"key":"R9-20250730","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/17474086.2022.2044780","article-title":"Hematological disorders in children with Down syndrome","volume":"15","author":"Triarico","year":"2022","journal-title":"Expert Rev Hematol"},{"key":"R10-20250730","doi-asserted-by":"crossref","first-page":"438","DOI":"10.12659\/AJCR.907847","article-title":"A rare case of relapsed pediatric acute promyelocytic leukemia with skin involvement by myeloid sarcoma","volume":"19","author":"Araujo","year":"2018","journal-title":"Am J Case Rep"},{"key":"R11-20250730","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/pbc.23201","article-title":"Superior outcome of pediatric acute myeloid leukemia patients with orbital and CNS myeloid sarcoma: a report from the Children's Oncology Group","volume":"58","author":"Johnston","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"R12-20250730","doi-asserted-by":"crossref","first-page":"749","DOI":"10.29271\/jcpsp.2020.07.749","article-title":"Clinical features and treatment outcomes of children with anaplastic large cell lymphoma","volume":"30","author":"Mehreen","year":"2020","journal-title":"J Coll Physicians Surg Pak"},{"key":"R13-20250730","doi-asserted-by":"crossref","DOI":"10.1007\/s00403-021-02293-0","article-title":"Differential survival of systemic B-cell lymphomas initially diagnosed in the skin: a population-based study of 883 patients","author":"Goyal","year":"2021","journal-title":"Arch Dermatol Res"},{"key":"R14-20250730","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/DAD.0000000000001061","article-title":"A Case of ALK+ anaplastic large-cell lymphoma with aberrant myeloperoxidase expression and initial cutaneous presentation","volume":"40","author":"Gru","year":"2018","journal-title":"Am J Dermatopathol"},{"key":"R15-20250730","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1111\/jdv.17219","article-title":"Dermoscopic and trichoscopic features of primary cutaneous lymphomas - systematic review","volume":"35","author":"Slawinska","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R16-20250730","first-page":"7","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J Clin"},{"issue":"(Suppl 2)","key":"R17-20250730","doi-asserted-by":"crossref","first-page":"e28473","DOI":"10.1002\/pbc.28473","article-title":"Neuroblastoma","volume":"68","author":"Chung","year":"2021","journal-title":"Pediatr Blood Cancer"},{"key":"R18-20250730","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.path.2020.08.002","article-title":"New prognostic indicators in pediatric adrenal tumors: neuroblastoma and adrenal cortical tumors, can we predict when these will behave badly?","volume":"13","author":"Jarzembowski","year":"2020","journal-title":"Surg Pathol Clin"},{"key":"R19-20250730","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.annemergmed.2021.07.131","article-title":"Infant with unilateral periorbital ecchymosis","volume":"79","author":"Dodderer","year":"2022","journal-title":"Ann Emerg Med"},{"key":"R20-20250730","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.clp.2020.11.006","article-title":"Neonatal neuroblastoma","volume":"48","author":"Davidoff","year":"2021","journal-title":"Clin Perinatol"},{"key":"R21-20250730","first-page":"479","article-title":"Cutaneous metastasis as the first manifestation of primary adrenal gland neuroblastoma in a pediatric patient","volume":"78","author":"Gonzalez-Mondragon","year":"2021","journal-title":"Bol Med Hosp Infant Mex"},{"key":"R22-20250730","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/cyt.13025","article-title":"Subcutaneous swellings as the initial presentation of malignancy in an infant: Highlighting the cytological mimics at the metastatic site","volume":"32","author":"Saharan","year":"2021","journal-title":"Cytopathology"},{"key":"R23-20250730","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1111\/1346-8138.15224","article-title":"Case of miliaria rubra histologically showing neutrophilic eccrine hidradenitis due to hyperhidrosis induced by a catecholamine-producing neuroblastoma","volume":"47","author":"Katayama","year":"2020","journal-title":"J Dermatol"},{"key":"R24-20250730","doi-asserted-by":"crossref","first-page":"e28920","DOI":"10.1002\/pbc.28920","article-title":"Metastatic neuroblastoma masquerading as infantile hemangioma in a 4-month-old child","volume":"68","author":"Karkoska","year":"2021","journal-title":"Pediatr Blood Cancer"},{"key":"R25-20250730","doi-asserted-by":"crossref","first-page":"e483","DOI":"10.1097\/MPH.0000000000001517","article-title":"A review of infants with localized neuroblastoma that evolve to stage 4s disease","volume":"42","author":"Caroleo","year":"2020","journal-title":"J Pediatr Hematol Oncol"},{"key":"R26-20250730","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.clp.2020.11.007","article-title":"Advances in the diagnosis and management of neonatal sarcomas","volume":"48","author":"Rashid","year":"2021","journal-title":"Clin Perinatol"},{"key":"R27-20250730","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/j.jpedsurg.2020.06.015","article-title":"Update on pediatric rhabdomyosarcoma: a report from the APSA Cancer Committee","volume":"55","author":"Rhee","year":"2020","journal-title":"J Pediatr Surg"},{"key":"R28-20250730","first-page":"e187","article-title":"Primary cutaneous alveolar rhabdomyosarcoma: report of a case and literature review","volume":"61","author":"Villarreal-Martinez","year":"2021","journal-title":"Int J Dermatol"},{"key":"R29-20250730","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/DAD.0000000000001560","article-title":"Epithelioid rhabdomyosarcoma: report of a cutaneous case and literature review of a recently described variant of rhabdomyosarcoma","volume":"42","author":"Valerio","year":"2020","journal-title":"Am J Dermatopathol"},{"key":"R30-20250730","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.3332\/ecancer.2021.1304","article-title":"Cutaneous metastases of embryonal rhabdomyosarcoma in a black African child: the role of dermoscopy in reducing time to and cost of diagnosis","volume":"15","author":"Enechukwu","year":"2021","journal-title":"Ecancermedicalscience"},{"key":"R31-20250730","first-page":"1338","article-title":"Rhabdomyosarcoma of the common bile duct mimicking choledochal cyst: a rare cause of obstructive jaundice","volume":"22","author":"Nazmul","year":"2020","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"R32-20250730","doi-asserted-by":"crossref","first-page":"e246751","DOI":"10.1136\/bcr-2021-246751","article-title":"Rare case of renal Ewing sarcoma presenting as ectopic Cushing syndrome in a 12-year-old girl","volume":"15","author":"Karguppikar","year":"2022","journal-title":"BMJ Case Rep"},{"key":"R33-20250730","doi-asserted-by":"crossref","first-page":"e29639","DOI":"10.1002\/pbc.29639","article-title":"Cutaneous mosaic RASopathies associated with rhabdomyosarcoma","volume":"69","author":"Davies","year":"2022","journal-title":"Pediatr Blood Cancer"},{"key":"R34-20250730","first-page":"233","article-title":"Langerhans cell histiocytosis-a benign presentation heralding a serious disease","volume":"19","author":"Gomes","year":"2021","journal-title":"Skinmed"},{"key":"R35-20250730","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/his.14569","article-title":"Cutaneous histiocytoses in children","volume":"80","author":"Fraitag","year":"2022","journal-title":"Histopathology"},{"key":"R36-20250730","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/pde.14389","article-title":"Langerhans cell histiocytosis in children: a retrospective case series of 126 cases","volume":"37","author":"Dhar","year":"2020","journal-title":"Pediatr Dermatol"},{"key":"R37-20250730","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/j.radcr.2021.04.028","article-title":"Multisystem langerhans cell histiocytosis in an infant","volume":"16","author":"Ji","year":"2021","journal-title":"Radiol Case Rep"},{"key":"R38-20250730","doi-asserted-by":"crossref","first-page":"e247213","DOI":"10.1136\/bcr-2021-247213","article-title":"Langerhans cell histiocytosis: an unusual cause of vesicular rashes in a neonate","volume":"14","author":"Wee","year":"2021","journal-title":"BMJ Case Rep"},{"key":"R39-20250730","doi-asserted-by":"crossref","first-page":"2050313X20919616","DOI":"10.1177\/2050313X20919616","article-title":"A neonate with Langerhans cell histiocytosis presenting as blueberry muffin rash: Case report and review of the literature","volume":"8","author":"Cyr","year":"2020","journal-title":"SAGE Open Med Case Rep"},{"key":"R40-20250730","doi-asserted-by":"crossref","first-page":"e162","DOI":"10.1111\/ajd.13491","article-title":"Cutaneous-group histiocytoses associated with myeloid malignancies: a systematic review of 102 cases","volume":"62","author":"Bonometti","year":"2021","journal-title":"Australas J Dermatol"},{"key":"R41-20250730","first-page":"6680635","article-title":"A dose-response relationship to radiotherapy for cutaneous lesions of langerhans cell histiocytosis","volume":"2021","author":"Farrugia","year":"2021","journal-title":"Case Rep Oncol Med"},{"key":"R42-20250730","doi-asserted-by":"crossref","first-page":"e640","DOI":"10.1111\/jdv.16509","article-title":"Cutaneous manifestations of Langerhans cell histiocytosis in children: a retrospective cohort study of 43 patients","volume":"34","author":"Ren","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R43-20250730","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1200\/JCO.19.00456","article-title":"Vemurafenib for refractory multisystem langerhans cell histiocytosis in children: an international observational study","volume":"37","author":"Donadieu","year":"2019","journal-title":"J Clin Oncol"},{"key":"R44-20250730","doi-asserted-by":"crossref","first-page":"e28712","DOI":"10.1002\/pbc.28712","article-title":"Langerhans cell histiocytosis with BRAF p.N486_P490del or MAP2K1 p.K57_G61del treated by the MEK inhibitor trametinib","volume":"67","author":"Messinger","year":"2020","journal-title":"Pediatr Blood Cancer"},{"key":"R45-20250730","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.3390\/ijms21062178","article-title":"Paraneoplastic dermatoses: a brief general review and an extensive analysis of paraneoplastic pemphigus and paraneoplastic dermatomyositis","volume":"21","author":"Didona","year":"2020","journal-title":"Int J Mol Sci"},{"key":"R46-20250730","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/1756-185X.13407","article-title":"Masked pemphigus among pediatric patients with Castleman's disease","volume":"22","author":"Han","year":"2019","journal-title":"Int J Rheum Dis"},{"key":"R47-20250730","first-page":"e19538","article-title":"Immune-mediated cutaneous paraneoplastic syndromes associated with hematologic malignancies: skin as a mirror of hematologic neoplasms","volume":"13","author":"Alvarez-Payares","year":"2021","journal-title":"Cureus"},{"key":"R48-20250730","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/ddg.14393","article-title":"Paraneoplastic pemphigus associated with Castleman's disease and thyroid carcinoma with anti-BP180, BP230 and antidesmocollin autoantibodies","volume":"19","author":"Velasco-Tamariz","year":"2021","journal-title":"J Dtsch Dermatol Ges"},{"key":"R49-20250730","doi-asserted-by":"crossref","first-page":"e14023","DOI":"10.1111\/petr.14023","article-title":"Paraneoplastic pemphigus associated with posttransplant lymphoproliferative disorder after small bowel transplantation","volume":"25","author":"Fidder","year":"2021","journal-title":"Pediatr Transplant"}],"container-title":["Current Opinion in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MOP.0000000000001152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T18:12:59Z","timestamp":1753899179000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MOP.0000000000001152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,5]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1097\/mop.0000000000001152","relation":{},"ISSN":["1040-8703","1531-698X"],"issn-type":[{"value":"1040-8703","type":"print"},{"value":"1531-698X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,5]]}}}