{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:47:33Z","timestamp":1791226053412,"version":"4.1.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1097\/mop.0b013e32834604f2","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T04:00:02Z","timestamp":1302753602000},"page":"319-324","source":"Crossref","is-referenced-by-count":93,"title":["The airway microbiome in cystic fibrosis and implications for treatment"],"prefix":"10.1097","volume":"23","author":[{"given":"Edith T","family":"Zemanick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D","family":"Sagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan K","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20210206","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1164\/rccm.200304-505SO","article-title":"Pathophysiology and management of pulmonary infections in cystic fibrosis","volume":"168","author":"Gibson","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"R2-11-20210206","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.prrv.2010.07.003","article-title":"Challenging and emerging pathogens in cystic fibrosis","volume":"11","author":"De Vrankrijker","year":"2010","journal-title":"Paediatr Respir Rev"},{"key":"R3-11-20210206","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1128\/CMR.00068-09","article-title":"The changing microbial epidemiology in cystic fibrosis","volume":"23","author":"LiPuma","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"R4-11-20210206","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1469-0691.2010.03236.x","article-title":"Detection and accurate identification of new or emerging bacteria in cystic fibrosis patients","volume":"16","author":"Bittar","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"R5-11-20210206","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/ppul.21221","article-title":"Pulmonary exacerbations in cystic fibrosis with negative bacterial cultures","volume":"45","author":"Zemanick","year":"2010","journal-title":"Pediatr Pulmonol"},{"key":"R6-11-20210206","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2217\/17460913.1.1.53","article-title":"Cystic fibrosis: a polymicrobial infectious disease","volume":"1","author":"Sibley","year":"2006","journal-title":"Future Microbiol"},{"key":"R7-11-20210206","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1586\/erm.09.81","article-title":"Lung infections in cystic fibrosis: deriving clinical insight from microbial complexity","volume":"10","author":"Rogers","year":"2010","journal-title":"Expert Rev Mol Diagn"},{"key":"R8-11-20210206","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1128\/MMBR.00014-10","article-title":"From structure to function: the ecology of host-associated microbial communities","volume":"74","author":"Robinson","year":"2010","journal-title":"Microbiol Mol Biol Rev"},{"key":"R9-11-20210206","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1078\/1438-4221-00265","article-title":"Molecular typing of the bacterial flora in sputum of cystic fibrosis patients","volume":"293","author":"Kolak","year":"2003","journal-title":"Int J Med Microbiol"},{"key":"R10-11-20210206","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1128\/JCM.41.8.3548-3558.2003","article-title":"Bacterial diversity in cases of lung infection in cystic fibrosis patients: 16S ribosomal DNA (rDNA) length heterogeneity PCR and 16S rDNA terminal restriction fragment length polymorphism profiling","volume":"41","author":"Rogers","year":"2003","journal-title":"J Clin Microbiol"},{"key":"R11-11-20210206","doi-asserted-by":"crossref","first-page":"5176","DOI":"10.1128\/JCM.42.11.5176-5183.2004","article-title":"Characterization of bacterial community diversity in cystic fibrosis lung infections by use of 16 s ribosomal DNA terminal restriction fragment length polymorphism profiling","volume":"42","author":"Rogers","year":"2004","journal-title":"J Clin Microbiol"},{"key":"R12-11-20210206","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0928-8244(99)00161-3","article-title":"Comparison of conventional and molecular methods for the detection of bacterial pathogens in sputum samples from cystic fibrosis patients","volume":"27","author":"van Belkum","year":"2000","journal-title":"FEMS Immunol Med Microbiol"},{"key":"R13-11-20210206","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1128\/AEM.66.7.2943-2950.2000","article-title":"Assessment of microbial diversity in four southwestern United States soils by 16S rRNA gene terminal restriction fragment analysis","volume":"66","author":"Dunbar","year":"2000","journal-title":"Appl Environ Microbiol"},{"key":"R14-11-20210206","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1128\/JCM.01324-09","article-title":"Determining cystic fibrosis-affected lung microbiology: comparison of spontaneous and serially induced sputum samples by use of terminal restriction fragment length polymorphism profiling","volume":"48","author":"Rogers","year":"2010","journal-title":"J Clin Microbiol"},{"key":"R15-11-20210206","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1128\/JCM.01650-10","article-title":"Analysis of the bacterial communities present in lungs of patients with cystic fibrosis from American and British centers","volume":"49","author":"Stressmann","year":"2011","journal-title":"J Clin Microbiol"},{"key":"R16-11-20210206","doi-asserted-by":"crossref","first-page":"20529","DOI":"10.1073\/pnas.0709804104","article-title":"Molecular identification of bacteria in bronchoalveolar lavage fluid from children with cystic fibrosis","volume":"104","author":"Harris","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R17-11-20210206","doi-asserted-by":"crossref","first-page":"e2908","DOI":"10.1371\/journal.pone.0002908","article-title":"Molecular detection of multiple emerging pathogens in sputa from cystic fibrosis patients","volume":"3","author":"Bittar","year":"2008","journal-title":"PLoS One"},{"key":"R18-11-20210206","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s10096-009-0749-x","article-title":"Microbial diversity in the sputum of a cystic fibrosis patient studied with 16S rDNA pyrosequencing","volume":"28","author":"Armougom","year":"2009","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"R19-11-20210206","doi-asserted-by":"crossref","first-page":"e120","DOI":"10.1093\/nar\/gkn491","article-title":"Accurate taxonomy assignments from 16S rRNA sequences produced by highly parallel pyrosequencers","volume":"36","author":"Liu","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"R20-11-20210206","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/ismej.2010.88","article-title":"Phylogenetic and metabolic diversity of bacteria associated with cystic fibrosis","volume":"5","author":"Guss","year":"2011","journal-title":"ISME J"},{"key":"R21-11-20210206","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00248-006-9134-9","article-title":"High-density universal 16S rRNA microarray analysis reveals broader diversity than typical clone library when sampling the environment","volume":"53","author":"DeSantis","year":"2007","journal-title":"Microb Ecol"},{"key":"R22-11-20210206","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/j.1462-2920.2010.02173.x","article-title":"Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosa","volume":"12","author":"Klepac-Ceraj","year":"2010","journal-title":"Environ Microbiol"},{"key":"R23-11-20210206","doi-asserted-by":"crossref","first-page":"e11044","DOI":"10.1371\/journal.pone.0011044","article-title":"Airway microbiota and pathogen abundance in age-stratified cystic fibrosis patients","volume":"5","author":"Cox","year":"2010","journal-title":"PLoS One"},{"key":"R24-11-20210206","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1099\/00222615-31-4-271","article-title":"The incidence of anaerobes in the sputum of patients with cystic fibrosis","volume":"31","author":"Jewes","year":"1990","journal-title":"J Med Microbiol"},{"key":"R25-11-20210206","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0022-3476(84)80051-7","article-title":"Sputum cultures for evaluation of anaerobes in cystic fibrosis","volume":"105","author":"Brook","year":"1984","journal-title":"J Pediatr"},{"key":"R26-11-20210206","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1172\/JCI0213870","article-title":"Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients","volume":"109","author":"Worlitzsch","year":"2002","journal-title":"J Clin Invest"},{"key":"R27-11-20210206","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.tim.2008.12.003","article-title":"Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways","volume":"17","author":"Hassett","year":"2009","journal-title":"Trends Microbiol"},{"key":"R28-11-20210206","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1164\/rccm.200708-1151OC","article-title":"Detection of anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis","volume":"177","author":"Tunney","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"R29-11-20210206","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1469-0691.2008.02659.x","article-title":"Antibiotic-resistant obligate anaerobes during exacerbations of cystic fibrosis patients","volume":"15","author":"Worlitzsch","year":"2009","journal-title":"Clin Microbiol Infect"},{"key":"R30-11-20210206","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.anaerobe.2010.04.002","article-title":"The genus Prevotella in cystic fibrosis airways","volume":"16","author":"Field","year":"2010","journal-title":"Anaerobe"},{"key":"R31-11-20210206","doi-asserted-by":"crossref","first-page":"e15101","DOI":"10.1371\/journal.pone.0015101","article-title":"Reliability of quantitative real-time PCR for bacterial detection in cystic fibrosis airway specimens","volume":"5","author":"Zemanick","year":"2010","journal-title":"PLoS One"},{"key":"R32-11-20210206","doi-asserted-by":"crossref","first-page":"15070","DOI":"10.1073\/pnas.0804326105","article-title":"A polymicrobial perspective of pulmonary infections exposes an enigmatic pathogen in cystic fibrosis patients","volume":"105","author":"Sibley","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R33-11-20210206","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1099\/jmm.0.016592-0","article-title":"McKay agar enables routine quantification of the \u2018Streptococcus milleri\u2019 group in cystic fibrosis patients","volume":"59","author":"Sibley","year":"2010","journal-title":"J Med Microbiol"},{"key":"R34-11-20210206","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1136\/thx.2010.137745","article-title":"Relative contribution of Prevotella intermedia and Pseudomonas aeruginosa to lung pathology in airways of patients with cystic fibrosis","volume":"65","author":"Ulrich","year":"2010","journal-title":"Thorax"},{"key":"R35-11-20210206","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.diagmicrobio.2008.06.011","article-title":"Assessing the diagnostic importance of nonviable bacterial cells in respiratory infections","volume":"62","author":"Rogers","year":"2008","journal-title":"Diagn Microbiol Infect Dis"},{"key":"R36-11-20210206","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.tim.2010.04.005","article-title":"Revealing the dynamics of polymicrobial infections: implications for antibiotic therapy","volume":"18","author":"Rogers","year":"2010","journal-title":"Trends Microbiol"},{"issue":"Suppl 2","key":"R37-11-20210206","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1097\/MCG.0b013e3181618ac7","article-title":"Probiotics in the treatment of human inflammatory bowel diseases: update 2008","volume":"42","author":"Fedorak","year":"2008","journal-title":"J Clin Gastroenterol"},{"key":"R38-11-20210206","first-page":"CD003048","article-title":"Probiotics for treating acute infectious diarrhoea.","volume":"11","author":"Allen","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"Suppl 2","key":"R39-11-20210206","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1097\/MCG.0b013e31815a57a8","article-title":"Bacterial colonization, probiotics, and necrotizing enterocolitis","volume":"42","author":"Claud","year":"2008","journal-title":"J Clin Gastroenterol"},{"key":"R40-11-20210206","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/ppul.21138","article-title":"Probiotic supplementation affects pulmonary exacerbations in patients with cystic fibrosis: a pilot study","volume":"45","author":"Weiss","year":"2010","journal-title":"Pediatr Pulmonol"},{"key":"R41-11-20210206","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.clnu.2007.01.004","article-title":"Effect of Lactobacillus GG supplementation on pulmonary exacerbations in patients with cystic fibrosis: a pilot study","volume":"26","author":"Bruzzese","year":"2007","journal-title":"Clin Nutr"}],"container-title":["Current Opinion in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MOP.0b013e32834604f2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T19:28:33Z","timestamp":1786044513000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00008480-201106000-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/mop.0b013e32834604f2","relation":{},"ISSN":["1040-8703"],"issn-type":[{"value":"1040-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}