{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T09:48:21Z","timestamp":1756460901326,"version":"3.40.4"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:sec>\n            <jats:title>Purpose of review<\/jats:title>\n            <jats:p>Intestinal transplantation (ITx) represents a major immunological challenge as the bidirectional exchange of donor's and recipient's immune cells delivers a graft highly chimeric and immunogenic. Therefore, there is a higher risk for immunological complications. It is important to understand the prevalence, natural history and mechanisms of other immunological complications, beyond rejection, to better understand the implications of ITx.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Recent findings<\/jats:title>\n            <jats:p>In recent studies, graft-versus-host disease (GVHD) holds a high mortality (43\u201370%). Apart from increasing or modifying immunosuppression, there are not other new therapies at this time. Inflammatory bowel disease (IBD) in solid organ transplant recipients has been estimated to be 10 times that of the general population. In the ITx recipient, it is not clear whether IBD is an autonomous disorder or a different phenotype of acute rejection. There are some studies suggesting that anti-tumour necrosis factor \u03b1 (anti-TNF\u03b1) may have a role in preventing or treating rejection. According to recent studies, the incidence of autoimmune hemolytic anemia is 11% and a large proportion of these patients will respond to conventional therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Summary<\/jats:title>\n            <jats:p>Rejection, GVHD, IBD-like disorder, autoimmune disorders and food allergies are among the more significant immunological complications after ITx. We need further studies to comprehend the risk factors and pathophysiology that will lead to better markers and innovative therapies that will impact survival.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/mot.0b013e32835337b2","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T14:05:46Z","timestamp":1333461946000},"page":"268-272","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Immunological complications beyond rejection after intestinal transplantation"],"prefix":"10.1097","volume":"17","author":[{"given":"Rub\u00e9n E.","family":"Quir\u00f3s-Tejeira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-11-20250502","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/0140-6736(91)92517-6","article-title":"Replacement of donor lymphoid tissue in small-bowel transplants.","volume":"337","author":"Iwaki","year":"1991","journal-title":"Lancet"},{"key":"R2-11-20250502","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1053\/j.gastro.2003.12.014","article-title":"IP-10-induced recruitment of CXCR3 host T cells is required for small bowel allograft rejection.","volume":"126","author":"Zhang","year":"2004","journal-title":"Gastroenterology"},{"key":"R3-11-20250502","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1182\/blood-2003-04-1187","article-title":"Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresias with immunodeficiency.","volume":"103","author":"Gilroy","year":"2004","journal-title":"Blood"},{"key":"R4-11-20250502","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1046\/j.1600-6143.2003.00137.x","article-title":"Minimal evidence of transdifferentiation from recipient bone marrow to parenchymal cells in regenerating cells in a long-surviving human allografts.","volume":"3","author":"Wu","year":"2003","journal-title":"Am J Transplant"},{"key":"R5-11-20250502","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1182\/blood-2003-06-1843","article-title":"Little evidence of donor-derived epithelial cells in early digestive acute graft-versus-host disease.","volume":"103","author":"Meignin","year":"2004","journal-title":"Blood"},{"key":"R6-11-20250502","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/j.1600-6143.2004.00524.x","article-title":"Graft versus host disease in intestinal transplantation.","volume":"4","author":"Mazariegos","year":"2004","journal-title":"Am J Transplant"},{"key":"R7-11-20250502","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/TP.0b013e3181ff86ec","article-title":"Graft-versus-host disease after intestinal and multivisceral 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