{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:24:35Z","timestamp":1790234675587,"version":"4.1.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1097\/mpa.0b013e31802f0531","type":"journal-article","created":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T04:00:21Z","timestamp":1174536021000},"page":"364-372","source":"Crossref","is-referenced-by-count":52,"title":["High Glucose Activates Rat Pancreatic Stellate Cells Through Protein Kinase C and p38 Mitogen-Activated Protein Kinase Pathway"],"prefix":"10.1097","volume":"34","author":[{"given":"Yoko","family":"Nomiyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuo","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taizo","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Asaumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Otsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-13-20210212","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/00006676-198701000-00010","article-title":"Pancreatic extracellular matrix alterations in chronic pancreatitis.","volume":"2","author":"Kennedy","year":"1987","journal-title":"Pancreas"},{"key":"R2-13-20210212","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1067\/msy.2002.119192","article-title":"Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas.","volume":"131","author":"Yen","year":"2002","journal-title":"Surgery"},{"key":"R3-13-20210212","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1136\/gut.43.1.128","article-title":"Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture.","volume":"43","author":"Apte","year":"1998","journal-title":"Gut"},{"key":"R4-13-20210212","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/gut.44.4.534","article-title":"Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis.","volume":"44","author":"Apte","year":"1999","journal-title":"Gut"},{"key":"R5-13-20210212","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/S0016-5085(00)70148-X","article-title":"Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells.","volume":"118","author":"Apte","year":"2000","journal-title":"Gastroenterology"},{"key":"R6-13-20210212","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0016-5085(98)70209-4","article-title":"Identification, culture, and characterization of pancreatic stellate cells in rats and humans.","volume":"115","author":"Bachem","year":"1998","journal-title":"Gastroenterology"},{"key":"R7-13-20210212","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1056\/NEJM199306243282508","article-title":"Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies.","volume":"328","author":"Friedman","year":"1993","journal-title":"N Engl J Med"},{"issue":"suppl 1","key":"R9-13-20210212","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000199541","article-title":"Conservative treatment of chronic pancreatitis.","volume":"37","author":"Lankisch","year":"1987","journal-title":"Digestion"},{"key":"R10-13-20210212","first-page":"31","article-title":"Chronic pancreatitis and diabetes.","volume":"74","author":"Petrin","year":"1983","journal-title":"Minerva Med"},{"key":"R11-13-20210212","first-page":"740","article-title":"Exocrine pancreatic function in diabetes mellitus.","volume":"7","author":"Groger","year":"1995","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R12-13-20210212","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1159\/000073655","article-title":"High prevalence of exocrine pancreatic insufficiency in diabetes mellitus. A multicenter study screening fecal elastase 1 concentrations in 1,021 diabetic patients.","volume":"3","author":"Hardt","year":"2003","journal-title":"Pancreatology"},{"key":"R13-13-20210212","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF00452061","article-title":"The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of death in patients under 20 years of age in the United Kingdom.","volume":"29","author":"Foulis","year":"1986","journal-title":"Diabetologia"},{"key":"R14-13-20210212","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2337\/diab.14.10.619","article-title":"Pathologic anatomy of the pancreas in juvenile diabetes mellitus.","volume":"14","author":"Gepts","year":"1965","journal-title":"Diabetes"},{"key":"R16-13-20210212","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00006676-200101000-00002","article-title":"Antifibrotic effect of the herbal medicine Saiko-keishi-to (TJ-10) on chronic pancreatitis in the WBN\/Kob rat.","volume":"22","author":"Su","year":"2001","journal-title":"Pancreas"},{"key":"R17-13-20210212","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1097\/00006676-200404000-00030","article-title":"Histopathologic difference between chronic pancreatitis animal models and human chronic pancreatitis.","volume":"28","author":"Suda","year":"2004","journal-title":"Pancreas"},{"key":"R18-13-20210212","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/00006676-199007000-00013","article-title":"Diabetic strain (WBN\/Kob) of rat characterized by endocrine-exocrine pancreatic impairment due to distinct fibrosis.","volume":"5","author":"Mori","year":"1990","journal-title":"Pancreas"},{"key":"R19-13-20210212","first-page":"185","article-title":"2nd, et al. Increased extracellular matrix synthesis and mRNA in mesangial cells grown in high-glucose medium.","volume":"260","author":"Ayo","year":"1991","journal-title":"Am J Physiol"},{"key":"R20-13-20210212","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1046\/j.1523-1755.2003.00824.x","article-title":"Glucose-induced fibronectin and collagen type III expression in renal fibroblasts can occur independent of TGF-beta1.","volume":"63","author":"Lam","year":"2003","journal-title":"Kidney Int"},{"key":"R21-13-20210212","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/hep.510300604","article-title":"Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis.","volume":"30","author":"Angulo","year":"1999","journal-title":"Hepatology"},{"key":"R22-13-20210212","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/0016-5085(92)90329-W","article-title":"Mechanism of insulin resistance associated with liver cirrhosis.","volume":"102","author":"Muller","year":"1992","journal-title":"Gastroenterology"},{"key":"R23-13-20210212","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0006-291X(05)81529-3","article-title":"Vascular smooth muscle cells exhibit increased growth in response to elevated glucose.","volume":"187","author":"Natarajan","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"key":"R24-13-20210212","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1172\/JCI116079","article-title":"Glucose-induced downregulation of angiotensin II and arginine vasopressin receptors in cultured rat aortic vascular smooth muscle cells. Role of protein kinase C.","volume":"90","author":"Williams","year":"1992","journal-title":"J Clin Invest"},{"key":"R25-13-20210212","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1053\/jhep.2001.28055","article-title":"High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis.","volume":"34","author":"Paradis","year":"2001","journal-title":"Hepatology"},{"key":"R26-13-20210212","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/j.1478-3231.2005.01130.x","article-title":"High glucose stimulates hepatic stellate cells to proliferate and to produce collagen through free radical production and activation of mitogen-activated protein kinase.","volume":"25","author":"Sugimoto","year":"2005","journal-title":"Liver Int"},{"key":"R27-13-20210212","first-page":"85","article-title":"High glucose-induced activation of protein kinase signaling pathways in vascular smooth muscle cells: a potential role in the pathogenesis of vascular dysfunction in diabetes.","volume":"9","author":"Srivastava","year":"2002","journal-title":"Int J Mol Med"},{"key":"R28-13-20210212","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/bbrc.2001.4310","article-title":"Role of PKC and TGF-beta receptor in glucose-induced proliferation of smooth muscle cells.","volume":"281","author":"Yasuda","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"R29-13-20210212","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diab.43.1.1","article-title":"Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy.","volume":"43","author":"Derubertis","year":"1994","journal-title":"Diabetes"},{"key":"R30-13-20210212","first-page":"571","article-title":"High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures.","volume":"261","author":"Ayo","year":"1991","journal-title":"Am J Physiol"},{"key":"R31-13-20210212","doi-asserted-by":"crossref","first-page":"847","DOI":"10.2337\/diab.46.5.847","article-title":"Mitogen-activated protein kinase cascade is activated in glomeruli of diabetic rats and glomerular mesangial cells cultured under high glucose conditions.","volume":"46","author":"Haneda","year":"1997","journal-title":"Diabetes"},{"key":"R32-13-20210212","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1248\/bpb.19.1518","article-title":"A combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazolium salt, neutral red and crystal violet.","volume":"19","author":"Ishiyama","year":"1996","journal-title":"Biol Pharm Bull"},{"key":"R33-13-20210212","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"R34-13-20210212","doi-asserted-by":"crossref","first-page":"18229","DOI":"10.1074\/jbc.M108065200","article-title":"Inhibition of collagen alpha 1(I) expression by the 5 stem-loop as a molecular decoy.","volume":"277","author":"Stefanovic","year":"2002","journal-title":"J Biol Chem"},{"key":"R35-13-20210212","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1046\/j.1523-1755.2001.059002673.x","article-title":"Glycated albumin stimulates TGF-beta 1 production and protein kinase C activity in glomerular endothelial cells.","volume":"59","author":"Chen","year":"2001","journal-title":"Kidney Int"},{"key":"R36-13-20210212","first-page":"684","article-title":"Glycated albumin stimulation of PKC-beta activity is linked to increased collagen IV in mesangial cells.","volume":"276","author":"Cohen","year":"1999","journal-title":"Am J Physiol"},{"key":"R37-13-20210212","doi-asserted-by":"crossref","first-page":"15771","DOI":"10.1016\/S0021-9258(18)98476-0","article-title":"The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.","volume":"266","author":"Toullec","year":"1991","journal-title":"J Biol Chem"},{"key":"R38-13-20210212","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1152\/ajprenal.00434.2004","article-title":"Mesangial cell-reduced Ca2+ signaling in high glucose is due to inactivation of phospholipase C-beta3 by protein kinase C.","volume":"289","author":"Frecker","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"R39-13-20210212","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1172\/JCI3326","article-title":"Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways.","volume":"103","author":"Igarashi","year":"1999","journal-title":"J Clin Invest"},{"key":"R40-13-20210212","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1124\/jpet.102.040287","article-title":"Inhibition of p38 mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells.","volume":"304","author":"Masamune","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"R41-13-20210212","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1155\/EDR.2000.89","article-title":"A new spontaneously diabetic non-obese Torii rat strain with severe ocular complications.","volume":"1","author":"Shinohara","year":"2000","journal-title":"Int J Exp Diabetes Res"},{"key":"R42-13-20210212","doi-asserted-by":"crossref","first-page":"F120","DOI":"10.1152\/ajprenal.00351.2002","article-title":"ERK and p38 mediate high-glucose-induced hypertrophy and TGF-beta expression in renal tubular cells.","volume":"286","author":"Fujita","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"R43-13-20210212","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1126\/science.1411571","article-title":"Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.","volume":"258","author":"Nishizuka","year":"1992","journal-title":"Science"},{"key":"R44-13-20210212","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.2337\/diab.46.9.1497","article-title":"Glucose-induced protein kinase C activation regulates vascular permeability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro.","volume":"46","author":"Williams","year":"1997","journal-title":"Diabetes"},{"key":"R45-13-20210212","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1046\/j.1523-1755.2000.07704.x","article-title":"Reactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose.","volume":"77","author":"Ha","year":"2000","journal-title":"Kidney Int Suppl"},{"key":"R46-13-20210212","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/bj3510095","article-title":"Specificity and mechanism of action of some commonly used protein kinase inhibitors.","volume":"351","author":"Davies","year":"2000","journal-title":"Biochem J"},{"key":"R47-13-20210212","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1172\/JCI114066","article-title":"Protein kinase C is activated in glomeruli from streptozotocin diabetic rats: possible mediation by glucose.","volume":"83","author":"Craven","year":"1989","journal-title":"J Clin Invest"},{"key":"R48-13-20210212","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1161\/01.ATV.0000144009.35400.65","article-title":"Altered PDGF-BB-induced p38 MAP kinase activation in diabetic vascular smooth muscle cells: roles of protein kinase C-delta.","volume":"24","author":"Yamaguchi","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R49-13-20210212","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/00006676-200308000-00008","article-title":"Pancreatic stellate cell activation by ethanol and acetaldehyde: is it mediated by the mitogen-activated protein kinase signaling pathway?","volume":"27","author":"McCarroll","year":"2003","journal-title":"Pancreas"}],"container-title":["Pancreas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MPA.0b013e31802f0531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:27:42Z","timestamp":1786033662000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006676-200704000-00013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/mpa.0b013e31802f0531","relation":{},"ISSN":["0885-3177"],"issn-type":[{"value":"0885-3177","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}