{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T04:04:29Z","timestamp":1750219469918,"version":"3.41.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>Abdominal pain\u2013related functional gastrointestinal disorders in children include functional dyspepsia, functional abdominal pain, irritable bowel syndrome, and abdominal migraine. We aimed to evaluate a possible association between functional abdominal pain disorders and <jats:italic>Helicobacter pylori<\/jats:italic> infection and faecal calprotectin level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Prospective observational study including consecutive children with functional gastrointestinal disorders fulfilling Rome III criteria (cases) and age\/sex\u2010matched healthy controls. <jats:italic>H pylori<\/jats:italic> has been detected by biopsy\u2010based tests and stool\u2010antigen detection, faecal calprotectin by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>A total of 56 cases (27 with functional dyspepsia) and 56 controls were enrolled. <jats:italic>H pylori<\/jats:italic> being detected in 17 of 56 cases (30.4%) and 4 of 56 controls (7.1%, odds ratio: 5.7; 95% confidence interval [CI]: 1.8\u201318.2, <jats:italic>P<\/jats:italic> = 0.003). <jats:italic>H pylori<\/jats:italic> was detected significantly more frequently in cases with functional dyspepsia (14\/27, 51.9% odds ratio: 14.0; 95% CI: 3.9\u201349.7, <jats:italic>P<\/jats:italic> = 0.00001) than in controls and not in cases with other well\u2010recognized functional gastrointestinal complaints (3\/29, 10.3%). The median faecal calprotectin level was similar in cases (7.8 \u03bcg\/g, 95% CI: 7.8\u20138.4) including those with gastritis, and controls (9.1 \u03bcg\/g, 95% CI: 7.8\u201311.3). Gastritis features were more frequent in <jats:italic>H pylori<\/jats:italic>\u2013infected and noninfected cases with functional dyspepsia (27\/27, 100%) than in cases with other abdominal functional complaints (15\/29, 51.7%, <jats:italic>P<\/jats:italic> = 0.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p><jats:italic>H pylori<\/jats:italic> gastritis and noninfectious gastritis were associated with functional dyspepsia in children referred for abdominal pain\u2013related functional gastrointestinal disorders while faecal calprotectin is not a predictor of gastritis and is similar in children with functional abdominal pain symptoms and in controls.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0000000000001172","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T11:07:19Z","timestamp":1456398439000},"page":"417-422","source":"Crossref","is-referenced-by-count":12,"title":["Paediatric Rome III Criteria\u2013Related Abdominal Pain Is Associated With <i>Helicobacter pylori<\/i> and Not With Calprotectin"],"prefix":"10.1002","volume":"63","author":[{"given":"Josef","family":"S\u00fdkora","sequence":"first","affiliation":[{"name":"Faculty of Medicine in Pilsen Faculty Hospital Department of Paediatrics Charles University in Prague"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Huml","sequence":"additional","affiliation":[{"name":"Faculty of Medicine in Pilsen Faculty Hospital Department of Paediatrics Charles University in Prague"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Siala","sequence":"additional","affiliation":[{"name":"Faculty of Medicine in Pilsen Faculty Hospital Department of Paediatrics Charles University in Prague"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e1ta","family":"Pomaha\u010dov\u00e1","sequence":"additional","affiliation":[{"name":"Faculty of Medicine in Pilsen Faculty 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