{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:11:24Z","timestamp":1791274284237,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>To measure concentrations of fecal calprotectin (f\u2010calprotectin) in infants with very low birth weight (VLBW; &lt;1500 g) longitudinally and to describe changes in f\u2010calprotectin in infants who develop severe abdominal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>The study included 59 VLBW infants. Seven patients (disease group) developed severe abdominal disease defined as necrotizing enterocolitis (NEC) or a condition leading to laparotomy. The remainder (n = 52) were considered reference infants and had a mean (\u00b1SD) gestational age of 27.2 \u00b1 2.6 weeks and a birth weight of 939 \u00b1 273 g. F\u2010calprotectin was analyzed in meconium and weekly during postnatal weeks 1 to 8. In disease cases, more frequent samples were analyzed around the time of abdominal disease diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>In reference infants the median (range) f\u2010calprotectin level in meconium was 332 (12\u20139386) \u03bcg\/g and correlated negatively to Apgar score. F\u2010calprotectin in postmeconium samples was 253 (9\u20131867) \u03bcg\/g and correlated positively to delivery by cesarean section, postnatal age, and volume of enteral feeds, and negatively to treatment with antibiotics and corticosteroids. In reference infants no postmeconium sample had f\u2010calprotectin levels &gt;2000 \u03bcg\/g. In disease cases f\u2010calprotectin was increased to &gt;2000 \u03bcg\/g in 3 cases of NEC and 1 case of covered perforation with microscopic bowel inflammation. In 1 case of NEC without microscopic bowel inflammation and 2 cases of focal intestinal perforation, f\u2010calprotectin levels never exceeded 2000 \u03bcg\/g.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>F\u2010calprotectin concentrations in VLBW infants are similar to previously reported levels in healthy term and moderately preterm infants. An f\u2010calprotectin level &gt;2000 \u03bcg\/g is a useful but not an early marker of NEC and other severe intestinal inflammatory conditions in VLBW infants.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3180320643","type":"journal-article","created":{"date-parts":[[2007,3,19]],"date-time":"2007-03-19T08:01:10Z","timestamp":1174291270000},"page":"407-413","source":"Crossref","is-referenced-by-count":81,"title":["Fecal Calprotectin in Very Low Birth Weight Infants"],"prefix":"10.1002","volume":"44","author":[{"given":"Stina","family":"Josefsson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Paediatrics Ume\u00e5 university Hospital Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K","family":"Bunn","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Royal Victoria Hospital Newcastle Upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Domell\u00f6f","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Paediatrics Ume\u00e5 university Hospital Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83354-2"},{"key":"e_1_2_6_3_1","first-page":"455","volume-title":"Pediatric Gastrointestinal Disease","author":"Kliegman RM","year":"1999"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81123-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/jpsu.2003.50162"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(91)90671-F"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/84.1.24"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/mp.50.3.113"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529209011186"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(99)00206-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750024551"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000201441"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2001.tb07239.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2002.tb01638.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197801000-00001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2002.tb07615.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2004.tb12120.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.59.3.236"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1997.67"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2003.tb00579.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.022368"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)80836-6"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199901000-00007"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000075306"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01541343"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12333-1"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.36696"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e3180320643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T12:10:34Z","timestamp":1705579834000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e3180320643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1097\/MPG.0b013e3180320643"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e3180320643","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}