{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:55:41Z","timestamp":1784832941014,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Acute diarrhea is an important cause of morbidity and mortality in children. Oral rehydration salts (ORS) have lowered mortality without having an effect on the duration or severity of diarrhea. Some studies have reported that heat\u2010killed <jats:italic>Lactobacillus<\/jats:italic> bacteria have a beneficial effect in the treatment of acute diarrhea. In this placebo\u2010controlled study the duration of diarrhea was compared for 2 types of treatment: <jats:italic>Lactobacillus<\/jats:italic> LB (Lacteol) in association with oral rehydration and oral rehydration alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>A total of 80 nondehydrated children between the ages of 3 months and 4 years with acute watery diarrhea were randomly assigned to be treated with <jats:italic>Lactobacillus<\/jats:italic> LB or placebo plus ORS. The primary endpoint was the duration of diarrhea; intake of ORS and change in body weight between the time of randomization and the last assessment were also measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>In 71 of the 80 patients, diarrhea was resolved: 36 in the <jats:italic>Lactobacillus<\/jats:italic> LB group and 35 in the placebo group. Several clinical characteristics of the 2 treatment groups were comparable at baseline. Median duration of diarrhea was 16.6 hours in the placebo group compared with 10.0 hours in the <jats:italic>Lactobacillus<\/jats:italic> LB group (<jats:italic>P<\/jats:italic> = 0.275). In the subgroup with a duration of diarrhea of more than 24 hours at inclusion, duration of diarrhea measured from that point was shorter for the <jats:italic>Lactobacillus<\/jats:italic> LB group (30.4 h vs 8.2 h; <jats:italic>P<\/jats:italic> = 0.044). ORS intake was similar for both groups. <jats:italic>Lactobacillus<\/jats:italic> LB was well tolerated, with only one patient experiencing an adverse effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p><jats:italic>Lactobacillus<\/jats:italic> LB is an effective and safe treatment for children with well\u2010established diarrhea (&gt;24 h).<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3180375594","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T08:05:12Z","timestamp":1177056312000},"page":"571-576","source":"Crossref","is-referenced-by-count":50,"title":["Effectiveness and Safety of Lactobacillus LB in the Treatment of Mild Acute Diarrhea in Children"],"prefix":"10.1002","volume":"44","author":[{"given":"Eduardo","family":"Salazar\u2010Lindo","sequence":"first","affiliation":[{"name":"Hospital Cayetano Heredia Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dante","family":"Figueroa\u2010Quintanilla","sequence":"additional","affiliation":[{"name":"Instituto Especializado de Salud del Ni\u00f1o Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Isabel","family":"Caciano","sequence":"additional","affiliation":[{"name":"Hospital Emergencias Pedi\u00e1tricas Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Reto\u2010Valiente","sequence":"additional","affiliation":[{"name":"Hospital Hipolito Unanue Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Chauviere","sequence":"additional","affiliation":[{"name":"Axcan Pharma Houdan France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Colin","sequence":"additional","affiliation":[{"name":"Axcan Pharma Houdan 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