{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T22:07:39Z","timestamp":1776895659090,"version":"3.51.2"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>For breast\u2010fed infants with rectal bleeding, maternal restriction of dietary protein such as cow's milk proteins is often recommended; however, poor response to dietary protein restriction is of concern. This pilot study was designed to assess the effectiveness of <jats:italic>Lactobacillus<\/jats:italic> GG (LGG) in breast\u2010fed infants with rectal bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>Breast\u2010fed infants &lt;6 months of age with rectal bleeding (defined as the presence of visible specks or streaks of blood mixed with mucus in the stool in otherwise healthy infants) were enrolled in a double\u2010blind randomized controlled trial in which they received LGG 3 \u00d7 10<jats:sup>9<\/jats:sup> colony\u2010forming units (n = 14) or placebo (n = 15) twice daily for 4 weeks as an adjunct to cow's milk restriction in the mother's diet. Analyses were based on allocated treatment and included data from 26 infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Mean duration of rectal bleeding was similar in the LGG and control groups (17.3 \u00b1 10.6 vs 15.4 \u00b1 11 days; mean difference \u22121.9 (95% confidence interval [CI] \u22124 to 7). No difference was found in the number of infants with clinical resolution of rectal bleeding within 72 hours and no relapse afterward (2\/11 vs 3\/15, relative risk [RR] 0.9, 95% CI 0.2\u20133.9) and the number of infants with clinical resolution of rectal bleeding within 72 hours followed by relapse of symptoms (5\/11 vs 5\/15, RR 1.4, 95% CI 0.5\u20133.5). Breast\u2010feeding cessation was not needed in any infant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>These results do not support the use of LGG as an adjunct to maternal cow's milk restriction in breast\u2010fed infants with rectal bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31804c505b","type":"journal-article","created":{"date-parts":[[2007,7,24]],"date-time":"2007-07-24T08:03:14Z","timestamp":1185264194000},"page":"247-251","source":"Crossref","is-referenced-by-count":19,"title":["Lack of Effect of <i>Lactobacillus<\/i> GG in Breast\u2010fed Infants With Rectal Bleeding: A Pilot Double\u2010blind Randomized Controlled Trial"],"prefix":"10.1002","volume":"45","author":[{"given":"H","family":"Szajewska","sequence":"first","affiliation":[{"name":"Second Department of Pediatrics Medical University of Warsaw Warsaw Poland"},{"name":"Department of Pediatric Gastroenterology and Nutrition Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Gawro\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Wo\u015b","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Banaszkiewicz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Grzybowska\u2010Chlebowczyk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Silesian Medical University Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01955182"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80008-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1994.tb11236.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(97)00136-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00943.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04259-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13490-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70093-9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7365.652"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1069"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-2244(00)89085-8"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03175.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308354"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01955182"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200001001-00009"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80008-5"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e31804c505b","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T14:02:42Z","timestamp":1705586562000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e31804c505b"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1097\/MPG.0b013e31804c505b"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e31804c505b","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}