{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:41:37Z","timestamp":1787244097987,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Our study aims to determine the age of onset of adult\u2010type hypolactasia in Sardinians, and to establish the age at which genotyping of the C\/T\u201013910 variant can be used reliably in the diagnosis of lactose malabsorption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>A lactose breath hydrogen test was given to 383 randomly selected patients, from 3 to 19 years old.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The C\/C\u201013910 genotype was found in 90% of patients; the frequency of the positive lactose breath hydrogen test increased with age and reached a prevalence of 85% at 9 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In Sardinians, adult\u2010type hypolactasia becomes phenotypically evident in all individuals older than 9 years, suggesting that this should be considered the minimum age at which the genetic test for lactase nonpersistence should be applied.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/mpg.0b013e31805b5899","type":"journal-article","created":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T18:07:40Z","timestamp":1236103660000},"page":"503-506","source":"Crossref","is-referenced-by-count":18,"title":["Decline of Lactase Activity and C\/T\u201013910 Variant in Sardinian Childhood"],"prefix":"10.1002","volume":"45","author":[{"given":"Enrico","family":"Schirru","sequence":"first","affiliation":[{"name":"Department of Pediatric Science and Clinical Medicine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Corona","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Biotechnology University of Cagliari Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Usai\u2010Satta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Unit AO G. Brotzu Hospital Cagliari"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Scarpa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Unit AO G. Brotzu Hospital Cagliari"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cucca","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science University of Sassari Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"De Virgiliis","sequence":"additional","affiliation":[{"name":"Department of Pediatric Science and Clinical Medicine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossano","family":"Rossino","sequence":"additional","affiliation":[{"name":"Department of Pediatric Science and Clinical Medicine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvia","family":"Frau","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Biotechnology University of Cagliari Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Doloretta","family":"Macis","sequence":"additional","affiliation":[{"name":"Department of Pediatric Science and Clinical Medicine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita\u2010D\u00e9sir\u00e9e","family":"Jores","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Biotechnology University of Cagliari Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Congia","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Microcitemico Hospital ASL n\u00b08 Cagliari"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.66.4.646"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-0620-8_1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1972.tb15897.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70429-9"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197512112932405"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409091742"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.040048"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng826"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1946"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","unstructured":"SchirruE CoronaV Usai\u2010SattaP et al. Genetic testing improves the diagnosis of adult type hypolactasia in the Mediterranean population of Sardinia.Eur J Clin Nutr2007; Feb 21; e\u2010pub ahead of print.","DOI":"10.1038\/sj.ejcn.1602638"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.3.582"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310000555a"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90313-1"},{"issue":"4","key":"e_1_2_5_16_1","first-page":"S63","article-title":"Evaluation of the accuracy of a portable device, gastrolyzer EC60 Bedfont, for hydrogen (H2) detection in expired air [abstract]","volume":"35","author":"Di Stefano M","year":"2003","journal-title":"Dig Liver Dis"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)93135-9"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199703000-00005"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/53.3.676"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.075127"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e31805b5899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T08:16:31Z","timestamp":1705565791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e31805b5899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1097\/MPG.0b013e31805b5899"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e31805b5899","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}