{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:07:57Z","timestamp":1705622877867},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>To assess the efficiency of determining IgA and IgG antigliadin antibodies (IgA\u2010 and IgG\u2010AGA, respectively), antitransglutaminase (TgA), and anti\u2010endomysial antibodies (AEA) in human umbilical cord (CO) and monkey esophagus for diagnosis of celiac disease; to determine the correlation between serological markers and celiac disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>A total of 400 patients were divided in 3 groups: group 1 with 37 patients with celiac disease, group 2 with 208 patients with no enteropathies, and group 3 with 155 patients with other enteropathies. IgA\u2010AGA, IgG\u2010AGA, and TgA were assessed using enzyme\u2010linked immunosorbent assay, whereas AEA was evaluated by indirect immunofluorescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Sensitivity and specificity of IgA\u2010AGA were 81.1% and 95.2%, of IgG\u2010AGA 89.2% and 95.2%, of TgA 83.9% and 96.8%, of AEA\u2010CO 87.9% and 100%, and of AEA of monkey esophagus 88.6% and 100%, respectively. Positive predictive values were 75.0%, 76.7%, 83.9%, and 100%. Negative predictive values were 96.6%, 98.0%, 96.8%, and 97.7% for IgA\u2010AGA, IgG\u2010AGA, TgA, and AEA, respectively. Multivariate analysis showed a strong association between AEA\u2010CO and celiac disease and a good correlation with other markers (TgA, IgA\u2010AGA, and IgG\u2010AGA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>TgA has been recommended for screening patients with celiac disease. Considering the similar sensitivity and specificity of IgA\u2010AGA and TgA and their correlations in the multivariate analysis, both are applicable for this purpose. However, because TgA tests are highly costly and celiac disease is associated with IgA deficiency, the determination of IgA\u2010AGA and IgG\u2010AGA, followed by AEA\u2010CO, is suitable for screening in developing countries, provided a cutoff point for these examinations is established. The results of antiendomysial antibodies in umbilical cord overlapped those in monkey esophagus. Therefore, umbilical cord should be used as a substrate instead of specimens from endangered species.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31805fe9b0","type":"journal-article","created":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T22:50:13Z","timestamp":1236120613000},"page":"551-558","source":"Crossref","is-referenced-by-count":5,"title":["Determining IgA and IgG Antigliadin, IgA Antitransglutaminase, and Antiendomysial Antibodies in Monkey Esophagus and in Umbilical Cord for Diagnosis of Celiac Disease in Developing Countries"],"prefix":"10.1002","volume":"45","author":[{"given":"Magda","family":"Bahia","sequence":"first","affiliation":[{"name":"Department of Complementary Medicine Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Jos\u00e9","family":"Penna","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan Barbosa 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