{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:39:16Z","timestamp":1792057156369,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>Endoluminal gastroplication (EG) is emerging as a minimally invasive procedure for the treatment of gastroesophageal reflux disease (GERD). The aim of this study is to evaluate the medium\u2010term outcomes after EG in a pediatric patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>Seventeen children with a median age of 12.4 years (range 6.1\u201315.9 years) with GERD underwent EG using a flexible endoscopic sewing device (EndoCinch) over a period of 3 years. Three plications were placed in the gastric tissue below the lower esophageal sphincter. Drug dose requirement, pH measurements, symptom severity and frequency, and validated Quality of Life in Reflux and Dyspepsia (QOLRAD) scores were compared before EG and 1 and 3 years after EG. Statistical analysis was performed using a Wilcoxon rank\u2010sum test and <jats:italic>P<\/jats:italic> &lt; 0.05 was the threshold for significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>All patients showed an immediate posttreatment improvement in symptom severity, symptom frequency, and quality of life scores. Completed 1\u2010 and 3\u2010year data were obtained from 16 patients. Four cases (25%) required a repeat procedure as a result of recurrence of symptoms after 2 to 24 months. Fourteen patients (88%) at 1 year and 9 patients (56%) at 3 years remained without a need for any antireflux medication. A sustained improvement in heartburn (<jats:italic>P<\/jats:italic> = 0.004), regurgitation (<jats:italic>P<\/jats:italic> = 0.017), and vomiting (<jats:italic>P<\/jats:italic> = 0.018) was seen at 3 years. The total QOLRAD score (maximum of 175) improved from a median of 87 (range 69\u2013142) to 156 (range 111\u2013175) at 1 year (<jats:italic>P<\/jats:italic> &lt; 0.0001) and 153.5 (range 55\u2013174) at 3 years (<jats:italic>P<\/jats:italic> = 0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>EG is an effective and safe procedure in children. It is a viable option for the treatment of GERD refractory to or dependent on antireflux medications.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31814d4de1","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T06:28:40Z","timestamp":1236234520000},"page":"172-177","source":"Crossref","is-referenced-by-count":29,"title":["Medium\u2010term Outcome of Endoluminal Gastroplication With the EndoCinch Device in Children"],"prefix":"10.1002","volume":"46","author":[{"given":"Mike","family":"Thomson","sequence":"first","affiliation":[{"name":"Centre for Paediatric Gastroenterology Sheffield Children's Hospital UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Antao","sequence":"additional","affiliation":[{"name":"Centre for Paediatric Gastroenterology Sheffield Children's Hospital UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Hall","sequence":"additional","affiliation":[{"name":"Royal Free Hospital UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Afzal","sequence":"additional","affiliation":[{"name":"Royal Free Hospital UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Hurlstone","sequence":"additional","affiliation":[{"name":"Hallamshire National Health Service Trust Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Paul","family":"Swain","sequence":"additional","affiliation":[{"name":"Royal London and St. Bartholomew's Hospitals National Health Service Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Fritscher\u2010Ravens","sequence":"additional","affiliation":[{"name":"Royal London and St. Bartholomew's Hospitals National Health Service Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909091032"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02064206"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90162-X"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-004-2279-z"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-002-9058-5"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-005-0501-2"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.4.468"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129689-200210000-00002"},{"issue":"3","key":"e_1_2_5_10_1","first-page":"146","article-title":"New endoscopic treatments for gastroesophageal reflux disease","volume":"11","author":"Ozawa S","year":"2005","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.041921"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-5157(02)00107-1"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/bega.1999.0011"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(86)71727-6"},{"key":"e_1_2_5_15_1","first-page":"AB35","article-title":"Sewing at flexible endoscopy in human gastrointestinal tract","volume":"40","author":"Swain CP","year":"1994","journal-title":"Gastrointest Endosc"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.8.1020"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04035.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.1.34"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-1610-4"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520410003579"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.058354"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-860994"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03932.x"},{"key":"e_1_2_5_24_1","first-page":"41","article-title":"Quality of life I reflux and dyspepsia patients. 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