{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:44:30Z","timestamp":1773297870150,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>Selective granulocyte\u2010monocyte adsorption (GMA) apheresis is a safe technique that has shown efficacy in inflammatory bowel disease (IBD), especially in adult steroid\u2010dependent and steroid\u2010refractory ulcerative colitis. GMA apheresis is performed with Adacolumn, a direct blood perfusion system that selectively adsorbs circulating granulocytes and monocytes. Studies on efficacy of GMA apheresis in paediatric IBD are scarce. Our aim was to evaluate efficacy, safety, and tolerability of GMA apheresis in paediatric IBD patients followed for 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>Nine patients with a mild to moderate flare\u2010up (6 boys, 3 girls; 5 ulcerative colitis [UC], 4 Crohn disease [CD]) were included. Mean age at inclusion was 13 years and 9 months, and mean disease duration before inclusion was 28 months. All of our patients with UC were steroid\u2010dependent; patients with CD had been unsuccessfully treated with other therapies. GMA apheresis consisted of 5 consecutive weekly sessions lasting 60 minutes each.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>After the 5 sessions, 4 of 5 patients with UC and 1 of 4 patients with CD achieved remission. This remission was maintained in 2 of 4 patients with UC and in the single patients with CD. Patients taking steroids could begin to taper their daily doses after the second apheresis, and 3 of 5 of these patients reached the end of the study steroid\u2010free. GMA apheresis was well tolerated and no severe side effects related to the technique were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>GMA apheresis is a safe, well\u2010tolerated technique in paediatric IBD. As previously reported, we have observed a better efficacy in promoting and maintaining remission, and reducing conventional drugs in patients with UC than in patients with CD.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31815604e5","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T17:34:46Z","timestamp":1236274486000},"page":"386-391","source":"Crossref","is-referenced-by-count":27,"title":["Safety and Efficacy of Granulocyte and Monocyte Adsorption Apheresis in Paediatric Inflammatory Bowel Disease: A Prospective Pilot Study"],"prefix":"10.1002","volume":"46","author":[{"given":"Javier","family":"Mart\u00edn de Carpi","sequence":"first","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology, and Nutrition Hospital Sant Joan de D\u00e9u Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pere","family":"Vilar","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology, and Nutrition Hospital Sant Joan de D\u00e9u Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Prieto","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Hospital La Paz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Dolores Garc\u00eda","family":"Novo","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology, and Nutrition Hospital El Ni\u00f1o Jes\u00fas Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Ribes","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology, and Nutrition Hospital La Fe Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Varea","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology, and Nutrition Hospital Sant Joan de D\u00e9u Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcgh.2003.50005"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020159932758"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200405000-00012"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02288.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1465-z"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20023"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.1000"},{"key":"e_1_2_5_9_1","first-page":"39","article-title":"Granulocyte apheresis in inflammatory bowel disease: possible mechanism of effect","volume":"2","author":"Rembaken 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