{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T10:22:41Z","timestamp":1774779761061,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim:<\/jats:title><jats:p>To evaluate gastric emptying of solids in children and adolescents with functional dyspepsia with and without <jats:italic>Helicobacter pylori<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>The study included 27 female patients (mean age 13.38 \u00b1 2.81 y) with functional dyspepsia according to Rome II criteria who were selected after upper gastrointestinal endoscopy found no major mucosal abnormality. Fragments were collected from the esophagus, gastric antrum, and gastric body for histological examination and rapid urease test. <jats:italic>H pylori<\/jats:italic> infection was diagnosed according to the rapid urease test and histological appearance. The histological appearance of the gastric mucosa was evaluated according to modified Sydney criteria. A <jats:sup>13<\/jats:sup>C\u2010octanoic breath test was performed after a test meal (2 slices of toasted bread, 10 g margarine, and 1 egg with 100 \u03bcLof the tracer dipped in the yolk) with 13 points of air collection in 4 hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Infection with <jats:italic>H pylori<\/jats:italic> was observed in 12 of 27 patients (44.4%). The gastric emptying half\u2010time was shorter in infected patients than in uninfected patients (mean \u00b1 SD 153.4 \u00b1 20.0 min vs 179.2 \u00b1 32.2 min; <jats:italic>P<\/jats:italic> = 0.019), as was the lag phase (106.3 \u00b1 22.6 vs 126.6 \u00b1 22.7 min; <jats:italic>P<\/jats:italic> = 0.038). There was no relationship between gastric emptying (half\u2010time and lag phase) and degree of histological abnormality. Vomiting and nausea were associated with slower gastric emptying in patients without <jats:italic>H pylori<\/jats:italic> gastritis more often than in infected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The study suggests that delayed gastric emptying can play an important role in a subgroup of dyspeptic patients, particularly those without <jats:italic>H pylori<\/jats:italic> infection who have nausea and vomiting.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e318159224e","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T17:34:46Z","timestamp":1236274486000},"page":"403-408","source":"Crossref","is-referenced-by-count":10,"title":["Gastric Emptying of Solids Is Slower in Functional Dyspepsia Unrelated to <i>Helicobacter pylori<\/i> Infection in Female Children and Teenagers"],"prefix":"10.1002","volume":"46","author":[{"given":"Rodrigo","family":"Strehl Machado","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology Escola Paulista de Medicina Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marialice","family":"Reber","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Escola Paulista de Medicina Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francy Reis","family":"da Silva Patr\u00edcio","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Escola Paulista de Medicina Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabete","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Escola Paulista de Medicina Universidade Federal de S\u00e3o Paulo 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