{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T14:11:33Z","timestamp":1778335893708,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>The natural history of paediatric inflammatory bowel diseases (IBDs) is poorly understood. We aim to describe the disease course in this cohort and generate prognostic information for patients and clinicians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>Patient records from 6 tertiary paediatric gastroenterology centres were reviewed to generate data concerning original diagnosis, change in diagnosis, family history, surgical interventions, growth, and presence of extragastrointestinal manifestations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Data were collected on 116 children with Crohn disease (CD), 74 with ulcerative colitis (UC), and 20 with indeterminate colitis (IC), followed for a mean period of 3.42, 3.3, and 2.9 years from date of diagnosis, respectively.<\/jats:p><jats:p>A male predominance is demonstrated in CD. Revision of diagnosis in patients with IC is mainly to UC, with most children receiving a definitive diagnosis within 2 years of initial presentation. Of the children with UC, 17.6% underwent 1 or more major operations with a median time to surgery of 1.92 years. Of children with CD, 11.6% underwent 1 or more major intraabdominal procedures with a median time to surgery of 1.83 years. We recorded a positive family history in 2.7%, 8.2%, and 10% of cases for CD, UC, and IC, respectively. For both boys and girls with CD, but only for boys with UC, height standard deviation score became more negative over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>This retrospective study quantifies certain distinctions between IBDs diagnosed in paediatric and adult populations. We document a trend toward male predominance in children with CD. We also note impaired linear growth in children with CD, whereas it appears maintained in girls with UC. We also have recorded a low incidence of IBDs in the families of this cohort and suggest that environmental influences may be of greater importance. We document that major intraabdominal surgery may be required in about 15% of patients with either UC or CD within 2 years of diagnosis, and that the majority of those diagnosed initially with IC will be reclassified as either UC or CD within 2 years.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181596efd","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T06:42:30Z","timestamp":1267080150000},"page":"539-545","source":"Crossref","is-referenced-by-count":45,"title":["Natural History of Paediatric Inflammatory Bowel Diseases Over a 5\u2010Year Follow\u2010up: A Retrospective Review of Data From the Register of Paediatric Inflammatory Bowel Diseases"],"prefix":"10.1002","volume":"46","author":[{"given":"Elizabeth A","family":"Newby","sequence":"first","affiliation":[{"name":"Countess of Chester Hospital Chester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick M","family":"Croft","sequence":"additional","affiliation":[{"name":"St. Bartholomew's and the London Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Green","sequence":"additional","affiliation":[{"name":"Leicester Royal Infirmary Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Hassan","sequence":"additional","affiliation":[{"name":"York Hill Children's Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert B","family":"Heuschkel","sequence":"additional","affiliation":[{"name":"Royal Free Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huw","family":"Jenkins","sequence":"additional","affiliation":[{"name":"University Hospital of Wales Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H","family":"Casson","sequence":"additional","affiliation":[{"name":"Alder Hey Children's Hospital Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.06.024"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.10.1432"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200003000-00009"},{"key":"e_1_2_5_5_1","unstructured":"NewbyEA SawczenkoA WilsonD et al. 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