{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:12:24Z","timestamp":1760955144786},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label \/><jats:p>In this study, we evaluated the expression of \u03b1\u2010defensin and its correlation with histological criteria in children with and without <jats:italic>Helicobacter pylori<\/jats:italic>\u2013associated gastritis. Forty\u2010five children were included. Immunohistochemical staining was performed and the relationship between \u03b1\u2010defensin immunoscoring and <jats:italic>H pylori<\/jats:italic> status and histological criteria was evaluated. Expression of \u03b1\u2010defensin was significantly higher in the <jats:italic>H pylori<\/jats:italic>\u2013positive group (<jats:italic>P<\/jats:italic> &lt; 0.001) and it was significantly associated with higher grades of chronic inflammation and neutrophil density (<jats:italic>P<\/jats:italic> &lt; 0.001 for both). Our data show that \u03b1\u2010defensin expression is increased in <jats:italic>H pylori<\/jats:italic> infection in childhood and is associated with inflammatory tissue damage.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31815a9923","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T17:34:46Z","timestamp":1236274486000},"page":"474-477","source":"Crossref","is-referenced-by-count":9,"title":["\u03b1\u2010Defensin Expression in the Gastric Tissue of Children with <i>Helicobacter pylori<\/i>\u2013Associated Chronic Gastritis: An Immunohistochemical Study"],"prefix":"10.1002","volume":"46","author":[{"given":"Ozlem Bekem","family":"Soylu","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition Unit Department of Pediatrics Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yesim","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition Unit Department of Pediatrics Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdener","family":"Ozer","sequence":"additional","affiliation":[{"name":"Department of Pathology Dokuz Eylul University Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2000.tb07169.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540600585131"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2002.tb07791.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01169.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(01)80690-3"},{"key":"e_1_2_6_7_1","first-page":"1","article-title":"Schistosomes, liver flukes, and Helicobacter pylori","volume":"61","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.","year":"1994","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2005.06.004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1452"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.40334.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(03)00158-5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.9.5412-5415.2000"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i1.99"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i31.4782"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.4.481"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00590.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0340263"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5034-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.08.028"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099250"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129039-200003000-00002"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.01992.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199807000-00003"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.6.1327"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.5.352"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2004.07.019"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e31815a9923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T12:15:55Z","timestamp":1705580155000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e31815a9923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1097\/MPG.0b013e31815a9923"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e31815a9923","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}