{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:06:27Z","timestamp":1782255987495,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>Lymphocytic gastritis (LG) is characterized by the presence of \u226525 lymphocytes\/100 epithelial cells in the gastric surface and pit epithelium. An association of LG with <jats:italic>Helicobacter pylori<\/jats:italic> infection or celiac disease (CD) has been suggested. The aim of this study was to verify the relation of LG with CD, with and without <jats:italic>H pylori<\/jats:italic> infection, in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>A total of 164 children with CD diagnosed between June 2003 and October 2005, in whom gastric and duodenal biopsies were performed simultaneously, were enrolled prospectively. The control group was composed of 164 children without CD, matched for sex and age, who were undergoing upper digestive endoscopy. <jats:italic>H pylori<\/jats:italic> was searched for in gastric biopsy specimens sectioned and stained with hematoxylin and eosin, and a modified Giemsa stain for <jats:italic>H pylori<\/jats:italic> was performed for confirmation. The Student <jats:italic>t<\/jats:italic> test was used to compare quantitative measurements between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>LG was found in 69 (42.1%) patients with CD. Positive cases had a mean of 43.9 \u00b1 1.5 intraepithelial lymphocytes per 100 surface epithelial cells, compared with a mean of 13.4 \u00b1 0.4 in negative cases and 7.8 \u00b1 0.5 in non\u2010CD control children (<jats:italic>P<\/jats:italic> &lt; 0.0001). Patients not showing LG did, however, show significantly increased gastric intraepithelial lymphocytes compared with the control children. Nine of 164 CD patients, and 4 of 69 patients with LG, had positive results for <jats:italic>H pylori<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>This study supports a pathogenetic relation between CD and LG. CD without LG also showed increased gastric intraepithelial lymphocytes. <jats:italic>H pylori<\/jats:italic> infection may be another cause of LG in children.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31816232a7","type":"journal-article","created":{"date-parts":[[2008,10,10]],"date-time":"2008-10-10T07:09:00Z","timestamp":1223622540000},"page":"568-572","source":"Crossref","is-referenced-by-count":19,"title":["Lymphocytic Gastritis and Celiac Disease in Indian Children: Evidence of a Positive Relation"],"prefix":"10.1002","volume":"47","author":[{"given":"Kaushal K","family":"Prasad","sequence":"first","affiliation":[{"name":"Division of GE Histopathology India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babu R","family":"Thapa","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadhna","family":"Lal","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun K","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Superspecialty of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chander K","family":"Nain","sequence":"additional","affiliation":[{"name":"Department of Superspecialty of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Superspecialty of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02962661"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(94)70254-3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199607000-00010"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2000.00038.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051867"},{"key":"e_1_2_5_8_1","first-page":"433","article-title":"Lymphocytic gastritis associated with gastric MALT lymphoma","volume":"21","author":"Heitzmann A","year":"1997","journal-title":"Gastroenterol Clin Biol"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.5.792"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.12.1123"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90819-M"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199902000-00003"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.8.909"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.5.628"},{"issue":"1","key":"e_1_2_5_15_1","first-page":"A39","article-title":"Celiac disease in Chandigarh: a population survey","volume":"24","author":"Lal S","year":"2005","journal-title":"Indian J Gastroenterol"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.9.1258"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199910000-00019"},{"key":"e_1_2_5_18_1","unstructured":"PrasadKK ThapaBR NainCK et al.Assessment of the diagnostic value of duodenal bulb histology in patients with celiac disease using multiple biopsy sites. J Clin Gastroenterol (in press)."},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05248.x"},{"key":"e_1_2_5_20_1","first-page":"26","article-title":"Lymphocytic gastritis: a study of its frequency and review of the literature","volume":"35","author":"Ribeiro VL","year":"1998","journal-title":"Arq Gastroenterol"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.51.3.207"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00621.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200012120-00004"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01082.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00741.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31804ca0ec"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03464.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(02)00014-2"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.7.741"},{"key":"e_1_2_5_30_1","first-page":"33","article-title":"T lymphocyte populations of the intestinal mucosa in celiac disease in children: immunohistochemical study","volume":"14","author":"Olives JP","year":"1990","journal-title":"Gastroenterol Clin Biol"},{"key":"e_1_2_5_31_1","first-page":"CR38","article-title":"Lymphocytic gastritis in pediatric celiac disease: immunohistochemical study of the intraepithelial lymphocytic component","volume":"10","author":"Drut R","year":"2004","journal-title":"Med Sci Monit"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91819-P"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.03.011"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.1.345"},{"key":"e_1_2_5_35_1","first-page":"208","article-title":"Lymphocytic gastritis: autoimmune disease or variant of Helicobacter gastritis","volume":"80","author":"Kushima R","year":"1996","journal-title":"Verh Dtsch Ges Pathol"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8698227"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90448-1"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520500349549"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.2.200"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e31816232a7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T13:30:13Z","timestamp":1705584613000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e31816232a7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1097\/MPG.0b013e31816232a7"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e31816232a7","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}