{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:48:42Z","timestamp":1790174922300,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We determined the occurrence of fructose malabsorption in pediatric patients with previous diagnoses of abdominal pain caused by a functional bowel disorder, whether the restriction of fructose intake changes the reporting of symptoms, the role of fructose dosage, and the severity of resultant symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>We administered a fructose breath test to children presenting with persistent unexplained abdominal pain. Patients randomly received 1, 15, or 45 g fructose, and breath hydrogen was measured for 3 hours after ingestion. Test results were positive when breath hydrogen was 20 ppm greater than baseline and was accompanied by gastrointestinal symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 32 patients was enrolled, and none of the 9 who received 1 g had positive results. Three of 10 who received 15 g and 8 of 13 who received 45 g had positive results. All patients with positive test results restricted their fructose intake. Among the group with positive results, 9 of 11 had rapid improvement of their gastrointestinal symptoms. After 2 months, all 9 patients continued to report improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We concluded that fructose malabsorption may be a significant problem in children and that management of dietary intake can be effective in reducing gastrointestinal symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/mpg.0b013e318166cbe4","type":"journal-article","created":{"date-parts":[[2008,8,19]],"date-time":"2008-08-19T03:07:55Z","timestamp":1219115275000},"page":"303-308","source":"Crossref","is-referenced-by-count":70,"title":["Fructose Intolerance in Children Presenting With Abdominal Pain"],"prefix":"10.1002","volume":"47","author":[{"given":"Robert E","family":"Gomara","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Gastroenterology and Nutrition New York Medical College Valhalla NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S","family":"Halata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Gastroenterology and Nutrition New York Medical College Valhalla NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard J","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Gastroenterology and Nutrition New York Medical College Valhalla NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard E","family":"Bostwick","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Gastroenterology and Nutrition New York Medical College Valhalla NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart H","family":"Berezin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Gastroenterology and Nutrition New York Medical College Valhalla NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynnette","family":"Cukaj","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Gastroenterology and Nutrition New York Medical College Valhalla NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary C","family":"See","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Gastroenterology and Nutrition New York Medical College Valhalla NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin S","family":"Medow","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Gastroenterology and Nutrition New York Medical College Valhalla NY 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