{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:55:17Z","timestamp":1788386117791,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Hepatoblastoma is the most common primary liver tumor in childhood and occurs more commonly in families with familial adenomatous polyposis. Germline mutations of the gene responsible for familial adenomatous polyposis\u2014adenomatous polyposis coli (<jats:italic>APC<\/jats:italic>)\u2014are described in patients with hepatoblastoma even without a family history. We investigated children presenting with apparently sporadic hepatoblastoma between 1991 and 2004. Blood samples were available from 29 children (18 boys) whose conditions were diagnosed at a median age of 22 months (range 6\u2013119 months). No germline APC mutations were found, which does not support the need for routine screening in sporadic hepatoblastoma in the absence of a suggestive family history of colorectal cancer or suspicion of familial adenomatous polyposis.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e318174e808","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T06:42:44Z","timestamp":1267080164000},"page":"675-677","source":"Crossref","is-referenced-by-count":25,"title":["Germline APC Mutations Are Not Commonly Seen in Children With Sporadic Hepatoblastoma"],"prefix":"10.1002","volume":"47","author":[{"given":"JJ","family":"Harvey","sequence":"first","affiliation":[{"name":"Cancer Research UK Molecular and Population Genetics Laboratory London Research Institute UK"},{"name":"Polyposis Registry St Mark's Hospital Harrow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SK","family":"Clark","sequence":"additional","affiliation":[{"name":"Polyposis Registry St Mark's Hospital Harrow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Hyer","sequence":"additional","affiliation":[{"name":"Polyposis Registry St Mark's Hospital Harrow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Hadzic","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IPM","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Cancer Research UK Molecular and Population Genetics Laboratory London Research Institute UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Hinds","sequence":"additional","affiliation":[{"name":"Department of Child Health King's College Hospital ing's College London School of Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02053203"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21470"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.04.019"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)24007-9"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20698"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-924730"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.02.004"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1309\/BF3MLJN8J527MWQY"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00005-1"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-199301000-00011"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.09.118"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-006-1834-1"},{"key":"e_1_2_5_14_1","first-page":"269","article-title":"Childhood hepatoblastomas frequently carry a mutation degradation targeting box of the beta\u2010catenin gene","volume":"59","author":"Koch A","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_5_15_1","first-page":"3320","article-title":"Somatic mutations of the APC gene in sporadic hepatoblastomas","volume":"56","author":"Oda H","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10362"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e318174e808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T13:29:28Z","timestamp":1705584568000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e318174e808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1097\/MPG.0b013e318174e808"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e318174e808","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}