{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:17:59Z","timestamp":1788837479106,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>We analyzed growth outcomes in children newly diagnosed with Crohn disease and determined whether growth abnormalities persist despite current therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>Clinical and growth data were prospectively obtained on an inception cohort younger than 16 years old at diagnosis and Tanner I to III during the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>In all, 176 children (mean age 10.1 years; 65% male) with mild (33%) or moderate\/severe (67%) disease at diagnosis were studied. Disease activity at 1 year was inactive\/mild (89%) or moderate\/severe (11%). First\u2010year treatments included immunomodulators (60%), corticosteroids (77%), 5\u2010aminosalicylates (61%), infliximab (15%), and enteral nutrition (10%). By 2 years, 86% had received immunomodulators and 36% infliximab. Mean height <jats:italic>z<\/jats:italic> scores at diagnosis, 1 year, and 2 years were \u22120.49 \u00b1 1.2 standard deviations (SDs), \u22120.50 \u00b1 1.2, and \u22120.46 \u00b1 1.1, respectively. Of the subjects, 10%, 8%, and 6.5% had height <jats:italic>z<\/jats:italic> scores less than \u22122 SD at diagnosis, 1 year, and 2 years. A height velocity <jats:italic>z<\/jats:italic> score less than \u22121SD was seen in 45% of subjects at 1 year and 38% at 2 years. The mean height velocity <jats:italic>z<\/jats:italic> score, however, increased between 1 and 2 years from \u22120.71 to 0.26 (<jats:italic>P<\/jats:italic> &lt; 0.03). Corticosteroid use greater than 6 months in the first year was associated with abnormal height velocity at 1 year (adjusted odds ratio = 4.5; 95% confidence interval [CI] = 2.2\u20139.6). No statistically significant effect on height velocity <jats:italic>z score<\/jats:italic>s was noted when comparing those receiving or not receiving infliximab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Growth delay persists in many children with CD following diagnosis, despite improved disease activity and the frequent use of immunomodulators and biologics. Additional strategies to improve growth outcomes require development.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e318175ca7f","type":"journal-article","created":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T08:18:03Z","timestamp":1233217083000},"page":"168-174","source":"Crossref","is-referenced-by-count":110,"title":["Growth Abnormalities Persist in Newly Diagnosed Children With Crohn Disease Despite Current Treatment Paradigms"],"prefix":"10.1002","volume":"48","author":[{"given":"Marian","family":"Pfefferkorn","sequence":"first","affiliation":[{"name":"Riley Hospital for Children Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgine","family":"Burke","sequence":"additional","affiliation":[{"name":"Connecticut Children's Medical Center Hartford CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children Toronto Ontario 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