{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:43:59Z","timestamp":1779338639227,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009054","name":"International Centre for Diarrhoeal Disease Research, Bangladesh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>Assess the safety of rapid intravenous rehydration of severely malnourished children and compare the efficacy of 3 formulations of oral rehydration salts solutions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>A group of 175 severely malnourished children of either sex (weight\/length &lt;70% of National Center for Health Statistics median), ages 6 to 36 months with cholera, were randomly assigned to receive 1 of 3 oral rehydration solutions (ORSs): glucose\u2010ORS (n = 58), glucose\u2010ORS plus 50 g\/L of amylase\u2010resistant starch (n = 59), or rice\u2010ORS (n = 58). Severely dehydrated children at enrollment were administered 100 mL\/kg of an intravenous solution for 4 to 6 hours before randomisation, and those with some dehydration were randomised on enrollment. The electrolytes of the 3 ORSs were identical. In acute and convalescence phases, treatment was similar other than the nature of the ORSs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Intravenous fluid (mean) administered to 149 study children was 103 mL\/kg (95% confidence interval [CI] 96\u2013109), and all were rehydrated within 6 hours. None of them developed overhydration or heart failure. During the first 24 hours, stool output (31%; 95% CI 14%\u201342%; <jats:italic>P<\/jats:italic> = 0.004) and the ORS intake (26%; 95% CI 12%\u201337%; <jats:italic>P<\/jats:italic> = 0.002) of children receiving rice\u2010ORS were significantly less compared with children receiving glucose\u2010ORS. The mean duration of diarrhoea in all children (66 hours; 95% CI 62\u201371), and time to attain 80% of median weight\/length (7.15 \u00b1 2.81 days) were not different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Dehydration in severely malnourished children can safely be corrected within 6 hours. All study ORSs were equally efficient in correcting dehydration. Rice\u2010ORS significantly reduced the stool output and ORS intake, confirming previous reports.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e318180af27","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T13:29:05Z","timestamp":1242912545000},"page":"318-327","source":"Crossref","is-referenced-by-count":47,"title":["Safety of Rapid Intravenous Rehydration and Comparative Efficacy of 3 Oral Rehydration Solutions in the Treatment of Severely Malnourished Children With Dehydrating Cholera"],"prefix":"10.1002","volume":"48","author":[{"given":"Nur H","family":"Alam","sequence":"first","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research Mohakhali Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sufia","family":"Islam","sequence":"additional","affiliation":[{"name":"East West University Mohakhali Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samima","family":"Sattar","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research Mohakhali Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirajum","family":"Monira","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research Mohakhali Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jehan\u2010Fran\u00e7ois","family":"Desjeux","sequence":"additional","affiliation":[{"name":"Conservatoire National des Arts et M\u00e9tiers Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13779-8"},{"key":"e_1_2_6_3_1","first-page":"223","article-title":"Why have mortality rates for severe malnutrition remained so high","volume":"74","author":"Schofield C","year":"1996","journal-title":"Bull WHO"},{"key":"e_1_2_6_4_1","volume-title":"WHO, UNICEF and SCN Informal Consultation on Community\u2010Based Management of Severe Malnutrition in Children","author":"World Health Organization, Severe Malnutrition in Children, United Nations Children's Fund.","year":"2006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.034306"},{"key":"e_1_2_6_6_1","volume-title":"Management of Severe Malnutrition: A Manual for Physicians and Other Senior Health Workers","author":"World Health Organization.","year":"1999"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07499-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)00329-3"},{"key":"e_1_2_6_9_1","volume-title":"The Treatment of Diarrhoea\u2010\u2010A Manual for Physicians and Other Senior Health Workers","author":"World Health Organization.","year":"1995"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.1.328S"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91341-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(86)80012-9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/45.5.1243"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1975.229.4.997"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.19.9.819"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01312224"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)30508-6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2000.tb07172.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.040089"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000214163.83316.41"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200002033420502"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6822.287"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/50.5.271"},{"key":"e_1_2_6_24_1","first-page":"91","article-title":"Risk factors for fatal diarrhoea among dehydrated malnourished children in a Madakaskar hospital","volume":"49","author":"Ravelomana N","year":"1995","journal-title":"Eur J Clin Nutr"},{"key":"e_1_2_6_25_1","first-page":"259","article-title":"Risk factors for mortality due to Shigellosis: a case\u2010control study among severely\u2010malnourished children in Bangladesh","volume":"23","author":"Van Den Broak JM","year":"2005","journal-title":"J Health Popul Nutr"},{"key":"e_1_2_6_26_1","unstructured":"Clinical growth charts.National Center for Health Statistics Web site.www.cdc.gov\/nchs\/about\/major\/nhanes\/growthcharts\/clinical_charts.htm. 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