{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:43:14Z","timestamp":1787010194930,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>In susceptible individuals, the adaptive response, mediated by the activation of antigen\u2010specific T lymphocytes, drives a proinflammatory response, which ends in an immune\u2010mediated enteropathy characterized by villous atrophy, crypt hyperplasia, and recruitment of intraepithelial lymphocytes. In addition, some gluten peptides are able to induce an innate immune response in intestinal mucosa. The molecular mechanisms and the cells involved in the initial stages of the gluten\u2013intestinal mucosa interaction are poorly understood to date. There is evidence of a direct toxic effect of gluten peptides in several biological models. However, the failure to control the inflammatory response may be one of the factors underlying gluten intolerance in these individuals. The cytokine network involved in celiac disease is characterized by abundant interferon\u2010\u03b3 in the intestinal mucosa. In addition, the production of interleukin (IL)\u201015, IL\u201018, and IL\u201021 is linked to gluten intake, which can drive the inflammatory response probably sustained by IL\u201018, IL\u201021, and perhaps IL\u201027 through STAT1 and STAT5 pathways, whereas neither IL\u201012 nor IL\u201023 plays a significant role in pathogenic mechanisms. Herein we describe the involvement of these activation pathways in the context of the pathogenesis of celiac disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181818fb9","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T16:34:19Z","timestamp":1236270859000},"source":"Crossref","is-referenced-by-count":75,"title":["Celiac Disease Pathogenesis: The Proinflammatory Cytokine Network"],"prefix":"10.1002","volume":"47","author":[{"given":"Jos\u00e9 Antonio","family":"Garrote","sequence":"first","affiliation":[{"name":"Mucosal Immunity Group Instituto de Biolog\u00eda y Gen\u00e9tica Molecular Universidad de Valladolid\u2010CSIC Spain"},{"name":"Research Unit Hospital Cl\u00ednico Universitario Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"G\u00f3mez\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Mucosal Immunity Group Instituto de Biolog\u00eda y 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