{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T14:36:35Z","timestamp":1773153395300,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["072789\/Z\/03\/Z"],"award-info":[{"award-number":["072789\/Z\/03\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000848","name":"University of Edinburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000848","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>To determine anti\u2010<jats:italic>Saccharomyces cerevisiae<\/jats:italic> antibodies (ASCA) status and its relation to disease phenotype in patients with inflammatory bowel disease (IBD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>A total of 301 Scottish patients with early\u2010onset IBD\u2014197 Crohn disease (CD), 76 ulcerative colitis (UC), 28 indeterminate colitis (IC)\u2014and 78 healthy control individuals were studied. ASCA status (IgA, IgG) was determined by enzyme\u2010linked immunosorbent assay. ASCA status was then analyzed in relation to CD phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Patients with CD had a higher prevalence of ASCA than patients with UC and healthy controls: 82\/197 versus 12\/76, odds ratio (OR) 3.80 (1.93\u20137.50) and 82\/197 versus 6\/78, OR 8.56 (3.55\u201320.62), respectively. Univariate analysis showed that positive ASCA status was associated with oral CD (17\/25 vs 59\/153, OR 3.39 [1.38\u20138.34]), perianal CD (39\/77 vs 38\/108, OR 1.89 [1.04\u20133.44]) and the presence of granulomata (63\/132 vs 15\/52, OR 2.25 [1.13\u20134.48]) and also with markers of disease severity: raised C\u2010reactive protein (44\/90 vs 12\/49, OR 2.95[1.36\u20136.37]), hypoalbuminemia (44\/85 vs 20\/74, OR 2.28[1.19\u20134.37]), and surgery (27\/49 vs 54\/147, OR 2.11 [1.10\u20134.06]). From multivariate analysis, the presence of oral disease (adjusted <jats:italic>P<\/jats:italic> = 0.001, OR 22.22 [3.41\u2013142.86]) and hypoalbuminemia (adjusted <jats:italic>P<\/jats:italic> = 0.01, OR 4.78 [1.40\u201316.39]) was found to be independently associated with ASCA status. No association was demonstrated between ASCA and IBD candidate genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Patients with CD had a higher prevalence of ASCA than did other patients with IBD. ASCA status described patients with CD who had a specific phenotype, showing an association with markers of disease severity and oral CD involvement.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e318183e112","type":"journal-article","created":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T08:18:03Z","timestamp":1233217083000},"page":"161-167","source":"Crossref","is-referenced-by-count":36,"title":["Anti\u2010<i>Saccharomyces cerevisiae<\/i> Antibodies Status Is Associated with Oral Involvement and Disease Severity in Crohn Disease"],"prefix":"10.1002","volume":"48","author":[{"given":"RK","family":"Russell","sequence":"first","affiliation":[{"name":"Department of Paediatric Gastroenterology Yorkhill Hospital UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Ip","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit Molecular Medicine Centre University of Edinburgh Western General Hospital 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