{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:04:19Z","timestamp":1789092259565,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>Sequential strategies combining the Kasai operation as a first\u2010line treatment and liver transplantation as a second\u2010line option, if necessary, have been accepted for patients with biliary atresia (BA). To understand the role of the Kasai operation in the treatment of BA, it is necessary to analyze the long\u2010term outcome of the operation alone and to evaluate the present status of survivors retaining their native livers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>A retrospective chart review was carried out for a group of 80 patients who had undergone the Kasai operation between 1970 and 1986 at the Kanagawa Children's Medical Center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The 5\u2010, 10\u2010, and 20\u2010year survival rates of patients with their native livers were 63%, 54%, and 44%, respectively. The survival rates varied significantly depending on the type of BA, age at initial Kasai operation, era of surgery, and surgical method. By age 20, nearly half of the adult survivors had already developed liver cirrhosis and its sequelae. Episodes of cholangitis and gastrointestinal bleeding occurred after 20 years of age in 37% and 17% of the adult patients, respectively, and 20% of the adult patients died of liver failure or underwent living\u2010related partial liver transplantation in their 20s. Five female patients gave birth to a total of 9 children, and 1 male patient fathered a child.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Although increasing numbers of patients with BA survive 20 years or more after the Kasai operation, meticulous lifelong postoperative care should be continued for the survivors because of the possibility of hepatic deterioration.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e318189f2d5","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T13:41:28Z","timestamp":1242913288000},"page":"443-450","source":"Crossref","is-referenced-by-count":139,"title":["Long\u2010term Outcome of Children With Biliary Atresia Who Were Not Transplanted After the Kasai Operation: &gt;20\u2010year Experience at a Children's Hospital"],"prefix":"10.1002","volume":"48","author":[{"given":"Masato","family":"Shinkai","sequence":"first","affiliation":[{"name":"Department of Surgery Kanagawa Children's Medical 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