{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:36:02Z","timestamp":1791351362542,"version":"4.3.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>The aim of the study was to evaluate early minimal enteral feeding (MEF) and gradual enteral nutrition increment on neonatal outcome of gastroschisis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>An intervention group was prospectively assessed and compared with an observational historical control group. The prospective study relied on a new protocol of enteral nutrition. According to the new protocol, MEF was initiated 5 days after bowel reintegration and milk amounts were increased 12 mL\/kg\/day. In the control group, enteral nutrition was delayed until resolution of postoperative ileus, and increment of feeding was not systematized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Twenty\u2010two patients were included in the MEF group and compared with 51 control patients. Infants in the control group had lower gestational age (36 vs 35 gestational weeks [GW], <jats:italic>P<\/jats:italic> = 0.03) and birth weight (2465 vs 2200 g, <jats:italic>P<\/jats:italic> = 0.05). Time to first enteral nutrition (5 vs 11.5 days, <jats:italic>P<\/jats:italic> = 0.0005) was significantly shorter in the MEF group. All patients in this group were fully enteral fed at day 60, though 30.4% of patients in the control group still needed parenteral nutrition at day 60 (<jats:italic>P<\/jats:italic> = 0.004). Incidence of nosocomial infection was reduced (9% of patients vs 40%, <jats:italic>P<\/jats:italic> = 0.016) and hospital stay tended to be shorter in the MEF group (40 vs 54.5 days, <jats:italic>P<\/jats:italic> = 0.08). In the univariate analysis, factors influencing the length of parenteral nutrition during the 2 periods were the severity of perivisceritis and new nutritional protocol. In the multivariate analysis, only nutritional protocol was significantly associated with the length of parenteral nutrition (<jats:italic>P<\/jats:italic> = 0.038).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Early MEF and controlled increase of nutritional elements after bowel reintegration significantly improved outcome of gastroschisis in newborns.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31818c5281","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T13:37:54Z","timestamp":1242913074000},"page":"612-617","source":"Crossref","is-referenced-by-count":55,"title":["Neonatal Outcome of Gastroschisis Is Mainly Influenced by Nutritional Management"],"prefix":"10.1002","volume":"48","author":[{"given":"Elizabeth","family":"Walter\u2010Nicolet","sequence":"first","affiliation":[{"name":"Department of Pediatrics France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Universit\u00e9 Paris\u2010Descartes Facult\u00e9 de M\u00e9decine AP\u2010HP H\u00f4pital Necker\u2010Enfants Malades France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Kieffer","sequence":"additional","affiliation":[{"name":"Department of Neonatology Institut de Pu\u00e9riculture de Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Fusaro","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Universit\u00e9 Paris\u2010Descartes Facult\u00e9 de M\u00e9decine AP\u2010HP H\u00f4pital Necker\u2010Enfants Malades France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Bourdaud","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Universit\u00e9 Paris\u2010Descartes Facult\u00e9 de M\u00e9decine AP\u2010HP H\u00f4pital Necker\u2010Enfants Malades France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salima","family":"Oucherif","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Universit\u00e9 Paris\u2010Descartes Facult\u00e9 de M\u00e9decine AP\u2010HP H\u00f4pital Necker\u2010Enfants Malades France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Benachi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Universit\u00e9 Paris\u2010Descartes Facult\u00e9 de M\u00e9decine AP\u2010HP H\u00f4pital Necker\u2010Enfants Malades France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Sarnacki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Universit\u00e9 Paris\u2010Descartes Facult\u00e9 de M\u00e9decine AP\u2010HP H\u00f4pital Necker\u2010Enfants Malades France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Mitanchez","sequence":"additional","affiliation":[{"name":"Department of Neonatology Universit\u00e9 Pierre et Marie Curie AP\u2010HP H\u00f4pital Armand Trousseau Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7538.424"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7536.250"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)01473-8"},{"key":"e_1_2_6_5_1","first-page":"917","article-title":"The gut: a central organ after surgical stress","volume":"104","author":"Wilmore DW","year":"1988","journal-title":"Surgery"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00075197-200211000-00011"},{"key":"e_1_2_6_7_1","first-page":"G1046","article-title":"Enteral nutrients promote postnatal maturation of intestinal motor activity in preterm infants","volume":"264","author":"Berseth CL","year":"1993","journal-title":"Am J Physiol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30308-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","unstructured":"TysonJE KennedyKA. 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