{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:17:37Z","timestamp":1790882257135,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives:<\/jats:title>\n                    <jats:p>Controversy exists regarding the optimal enteral feeding regimen of very low birth weight infants (VLBW). Rapid advancement of enteral feeding has been associated with an increased rate of necrotizing enterocolitis. In contrast, delaying enteral feeding may have unfavorable effects on nutrition, growth, and neurodevelopment. The aim is to compare the short\u2010term outcomes of VLBW infants in tertiary care centers according to their enteral feeding advancement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>We prospectively studied the influence of center\u2010specific enteral feeding advancement in 1430 VLBW infants recruited from 13 tertiary neonatal intensive care units in Germany on short\u2010term outcome parameters. The centers were post hoc stratified to \u201crapid advancement to full enteral feeds\u201d (median duration of advancement to full enteral feeds \u226412.5 days; 6 centers), that is, rapid advancement (RA), or \u201cslow advancement to full enteral feeds\u201d (median duration of advancement to full enteral feeds &gt;12.5 days; 7 centers), that is, slow advancement (SA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      VLBW infants born in centers with SA (n = 713) had a significantly higher rate of sepsis compared with VLBW infants born in centers with RA (n = 717), which was particularly evident for late\u2010onset sepsis (14.0% vs 20.4%;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002). Furthermore, more central venous lines (48.6% vs 31.1%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) and antibiotics (92.4% vs 77.7%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) were used in centers with SA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Center differences in enteral feeding advancement occur and may have a significant impact on short\u2010term outcomes such as nosocomial sepsis. Large, multicenter, prospective trials are required to further elucidate the optimal feeding strategy for VLBW infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/mpg.0b013e31818c5fc3","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T09:41:28Z","timestamp":1242898888000},"page":"464-470","source":"Crossref","is-referenced-by-count":47,"title":["Does the Enteral Feeding Advancement Affect Short\u2010term Outcomes in Very Low Birth Weight Infants?"],"prefix":"10.1002","volume":"48","author":[{"given":"Christoph","family":"H\u00e4rtel","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Haase","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Browning\u2010Carmo","sequence":"additional","affiliation":[{"name":"Grace Center for Newborn Care Children's Hospital Westmead Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Gebauer","sequence":"additional","affiliation":[{"name":"University Children's Hospital Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Kattner","sequence":"additional","affiliation":[{"name":"Children's Hospital auf der Bult Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Kribs","sequence":"additional","affiliation":[{"name":"Children's Hospital University of Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Segerer","sequence":"additional","affiliation":[{"name":"Children's Hospitals St Hedwig Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Teig","sequence":"additional","affiliation":[{"name":"University of Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel von der","family":"Wense","sequence":"additional","affiliation":[{"name":"Hamburg\u2010Altona Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Wieg","sequence":"additional","affiliation":[{"name":"Aschaffenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egbert","family":"Herting","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"G\u00f6pel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"KennedyKA TysonJE ChamnanvanikijS. Rapid versus slow rate of advancement of feedings for promoting growth and preventing necrotizing enterocolitis in parenterally fed low\u2010birth\u2010weight infants.Cochrane Database Syst Rev2000:CD001241."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2007.02.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70452-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","unstructured":"TysonJE KennedyKA. 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