{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:41:26Z","timestamp":1725496886215},"reference-count":11,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label \/><jats:p>The colon is actively implicated in intestinal infections not only as a target of enteric pathogens and their products but also as a target organ for treatment. In the presence of diarrhea, both of osmotic and secretory nature, the colon reacts with homeostatic mechanisms to increase ion absorption. These mechanisms can be effectively exploited to decrease fluid discharge. A model of intestinal infections using rotavirus (RV) in colonic cells was set up and used to define a dual model of secretory and osmotic diarrhea in sequence. Using this model, antidiarrheal drugs were tested, namely zinc and the enkephalinase inhibitor racecadotril. Zinc was able to decrease the enterotoxic activity responsible for secretory diarrhea. It also inhibited the cytotoxic effect of RV. The mechanism of zinc was related at least in part to the activation of MAPK activity, but also a direct antiviral effect was observed. Racecadotril showed a potent and selective inhibition of active secretion, being particularly effective in the first phase of RV diarrhea. The use of drugs active at the colonic level, therefore, offers effective options to treat intestinal infections in childhood. In addition, the colon is the natural site of colonic microflora, a target of probiotic therapy, which is the first line of approach recommended by the European Society for Paediatric Gastroenterology, Hepatology and Nutrition to treat infectious diarrhea.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181a1188b","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T09:36:52Z","timestamp":1242898612000},"source":"Crossref","is-referenced-by-count":5,"title":["Colon in Acute Intestinal Infection"],"prefix":"10.1002","volume":"48","author":[{"given":"Alfredo","family":"Guarino","sequence":"first","affiliation":[{"name":"Department of Paediatrics University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittoria","family":"Buccigrossi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Armellino","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/advan.00092.2007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/314427"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(94)94093-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000069841.52414.A5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e328317c897"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","unstructured":"De MarcoG BuccigrossiV BracaleI et al.NSP4 plays a major role in the early secretory diarrhea induced by rotavirus in a Caco\u20102 experimental model. Paper presented at the 38th annual meeting of ESPGHAN Porto Portugal June 1\u20104 2005.","DOI":"10.1097\/00005176-200505000-00049"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.6.1516"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2007.03.008"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/428504"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090308"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32831b4455"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e3181a1188b","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T09:10:47Z","timestamp":1705569047000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e3181a1188b"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":11,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1097\/MPG.0b013e3181a1188b"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e3181a1188b","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}