{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:40:01Z","timestamp":1760888401162},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Total esophagogastric dissociation (TED) was first described in 1997 by Bianchi as a new surgical procedure to treat severe gastroesophageal reflux disease (GERD) in children with neurological impairment. Recently, TED has been proposed in other conditions, such as esophageal atresia, esotracheal cleft, or caustic esophageal lesions. Although the long\u2010term results in terms of GERD control have been previously reported, those regarding the nutritional and metabolic status have never been documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>All patients without neurological impairment with TED between 1999 and 2004 at Robert Debre Hospital and Jeanne de Flandre Hospital, France, were prospectively investigated, paying particular attention to their metabolic and nutritional status (blood concentration of iron and vitamins A, D, E, and B<jats:sub>12<\/jats:sub>; lipid malabsorption; and hyperglycemia test) and growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Seventeen children underwent TED. Six received primary procedures, whereas 11 were operated on because of severe respiratory diseases or failure to thrive. The mean follow\u2010up was 6 years (range 3\u20138 years). Two children died (12%). Seven children were weaned from enteral nutrition support, but 5 of them had failure to thrive, steatorrhea, and\/or malabsorption of vitamin B<jats:sub>12<\/jats:sub> and\/or fat\u2010soluble vitamins. Eight patients had dumping syndrome, which was symptomatic in 6 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>TED is an effective procedure for treatment of GERD. However, nutritional and metabolic complications including dumping syndrome and chronic digestive malabsorption are frequent after TED, especially after enteral nutrition weaning. A long\u2010term follow\u2010up of these patients is thus necessary and prolonged enteral nutrition support is recommended.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181a159fa","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T06:43:05Z","timestamp":1267080185000},"page":"280-286","source":"Crossref","is-referenced-by-count":13,"title":["Prolonged Enteral Feeding Is Often Required to Avoid Long\u2010term Nutritional and Metabolic Complications After Esophagogastric Dissociation"],"prefix":"10.1002","volume":"50","author":[{"given":"Chryst\u00e8le","family":"Madre","sequence":"first","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris Universit\u00e9 Paris Diderot H\u00f4pital Robert Debr\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"Serhal","sequence":"additional","affiliation":[{"name":"H\u00f4pital Jeanne de Flandre Universit\u00e9 Lille2 Lille CHRU de Lille 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