{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:44:40Z","timestamp":1779925480122,"version":"3.53.1"},"reference-count":12,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Chronic constipation is one of the most frequent complaints in childhood. Although there is evidence that gastrointestinal flora is important in gut motility, there is little evidence that gut flora is abnormal in constipation. Lactobacilli and bifidobacteria increase stool frequency and decrease consistency in normal individuals. But, according to several reviews, the evidence of probiotics for efficacy in constipation is limited. Fiber supplements, lactose\u2010free diets, and lactobacillus supplementation are effective in the management of children with recurrent abdominal pain and irritable bowel syndrome. Several studies with Lactobacillus GG in children showed negative results in children with chronic constipation. Because <jats:italic>Bifidobacterium animalis<\/jats:italic> DN\u2010173 010 has been shown to be effective in adults with constipation\u2010predominant irritable bowel syndrome this study should also be performed in a well\u2010designed large placebo\u2010controlled trial in children with constipation.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181a1603a","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T13:36:52Z","timestamp":1242913012000},"source":"Crossref","is-referenced-by-count":24,"title":["Probiotics and Functional Gastrointestinal Disorders in Children"],"prefix":"10.1002","volume":"48","author":[{"given":"Yvan","family":"Vandenplas","sequence":"first","affiliation":[{"name":"UZ Brussel Kinderen Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Benninga","sequence":"additional","affiliation":[{"name":"Emma Children's Hospital\/AMC Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00771.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.065"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.08.063"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02615.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.05.015"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03175.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.10.022"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-6-17"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2007.02397.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000221913.88511.72"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","unstructured":"Huertas\u2010CeballosA LoganS BennettC MacarthurC.Dietary interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood. Cochrane Database Syst Rev.2008:CD003019.","DOI":"10.1002\/14651858.CD003019.pub2"},{"key":"e_1_2_7_13_1","unstructured":"MoranJP WalterJW TannockGW et al.Bifidobacterium animalis causes extensive duodenitis and mild colonic inflammation in monoassociated interleukin\u201010\u2010deficient mice. Inflamm Bowel Dis. In press."}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e3181a1603a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T14:11:01Z","timestamp":1705587061000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e3181a1603a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":12,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1097\/MPG.0b013e3181a1603a"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e3181a1603a","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}