{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:29:05Z","timestamp":1782815345645,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>Patients with cystic fibrosis (CF) presenting with meconium ileus (MI) tend to have worse outcomes than those without MI. We evaluated the clinical characteristics and survival rates among Israeli patients with CF with and without MI after a prolonged follow\u2010up (15\u201330 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>A multicenter retrospective study. Forty\u2010nine patients with CF, representing 13.8% of all patients with CF in Israel, presented with MI (current age 17.4 \u00b1 7.9 years) between 1975 and 2006. They were compared with 38 patients with CF (current age 19.3 \u00b1 6.5 years) without MI matched by sex and CF transmembrane conductance regulator mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>A total of 66.2% of patients with MI and 73.6% without MI were followed for a prolonged period (24.9 \u00b1 2.7 years). Of the patients with MI, 31 were managed operatively, whereas 18 were treated successfully with gastrograffin enema, with similar clinical outcomes. Five patients in the MI group and 3 in the control group died during the study period. Bacterial colonization, <jats:italic>z<\/jats:italic> score of body mass index, and pulmonary function tests were similar in patients with and without MI in the long term. In younger patients, many clinical parameters were more prevalent in patients with MI (<jats:italic>P<\/jats:italic> = 0.004). However, these differences disappeared after the long\u2010term follow\u2010up (up to 31\u2010years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Patients with CF presenting with MI had similar pulmonary function and nutritional status, as well as survival rates as did the control patients without MI. The distinct genetic mutation found in our population may explain in part the favorable results compared with other studies. In addition, it seems that early diagnosis and treatment of MI in patients with CF may be beneficial, subsequently lowering morbidity, and increasing survival.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181a3bfdd","type":"journal-article","created":{"date-parts":[[2010,1,16]],"date-time":"2010-01-16T07:55:16Z","timestamp":1263628516000},"page":"173-178","source":"Crossref","is-referenced-by-count":38,"title":["Meconium Ileus in Patients With Cystic Fibrosis Is Not a Risk Factor for Clinical Deterioration and Survival: The Israeli Multicenter Study"],"prefix":"10.1002","volume":"50","author":[{"given":"Ori","family":"Efrati","sequence":"first","affiliation":[{"name":"Pediatric Pulmonology Unit Safra Children's Hospital Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Nir","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit Safra Children's Hospital Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drora","family":"Fraser","sequence":"additional","affiliation":[{"name":"Epidemiology Department Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malena","family":"Cohen\u2010Cymberknoh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and the Cystic Fibrosis Center Hadassah\u2010Hebrew University Medical Center Mount Scopus Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Shoseyov","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and the Cystic Fibrosis Center Hadassah\u2010Hebrew University Medical Center Mount Scopus Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphna","family":"Vilozni","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit Safra Children's Hospital Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalit","family":"Modan\u2010Moses","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit Safra Children's Hospital Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Levy","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit Safra Children's Hospital Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Szeinberg","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit Safra Children's Hospital Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitan","family":"Kerem","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and the Cystic Fibrosis Center Hadassah\u2010Hebrew University Medical Center Mount Scopus Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Rivlin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Carmel Medical Center Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Patient Registry 2000 Annual Data Report","author":"Cystic Fibrosis Foundation.","year":"2001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.jpedsurg.2006.05.014","article-title":"Clinical outcome of cystic fibrosis presenting with or without meconium ileus: a matched cohort study","volume":"41","author":"Munck A","year":"2006","journal-title":"J Pediatr Surg"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1183\/09031936.01.00053701","article-title":"The impact of meconium ileus on the clinical course of children with cystic fibrosis","volume":"18","author":"Evans AK","year":"2001","journal-title":"Eur Respir J"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1542\/peds.101.4.e7","article-title":"Long\u2010term outcome after neonatal meconium obstruction","volume":"101","author":"Fuchs JR","year":"1998","journal-title":"Pediatrics"},{"key":"e_1_2_5_6_1","first-page":"699","article-title":"Meconium ileus: a fifteen\u2010year experience with forty\u2010two neonates","volume":"102","author":"Caniano DA","year":"1987","journal-title":"Surgery"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/aje\/kwh083","article-title":"Association between initial disease presentation, lung disease outcomes, and survival in patients with cystic fibrosis","volume":"159","author":"Lai HJ","year":"2004","journal-title":"Am J Epidemiol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.107.1.1","article-title":"Early diagnosis of cystic fibrosis through neonatal screening prevents severe malnutrition and improves long\u2010term growth. Wisconsin Cystic Fibrosis Neonatal Screening Study Group","volume":"107","author":"Farrell PM","year":"2001","journal-title":"Pediatrics"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1136\/fn.80.1.F1","article-title":"Clinical outcomes of newborn screening for cystic fibrosis","volume":"80","author":"Waters DL","year":"1999","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1183\/09031936.01.00080101","article-title":"Influence of neonatal screening and centralized treatment on long\u2010term clinical outcome and survival of CF patients","volume":"18","author":"Merelle ME","year":"2001","journal-title":"Eur Respir J"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/aje\/kwf064","article-title":"Epidemiology and survival analysis of cystic fibrosis in an area of intense neonatal screening over 30 years","volume":"156","author":"Assael BM","year":"2002","journal-title":"Am J Epidemiol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1542\/peds.105.1.53","article-title":"Nutritional status of patients with cystic fibrosis with meconium ileus: a comparison with patients without meconium ileus and diagnosed early through neonatal screening","volume":"105","author":"Lai HC","year":"2000","journal-title":"Pediatrics"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/ppul.20092","article-title":"Longitudinal pulmonary status of cystic fibrosis children with meconium ileus","volume":"38","author":"Li Z","year":"2004","journal-title":"Pediatr Pulmonol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(88)91180-4","article-title":"Genetic differences between cystic fibrosis with and without meconium ileus","volume":"1","author":"Mornet E","year":"1988","journal-title":"Lancet"},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF00442105","article-title":"Familial occurrence of meconium ileus","volume":"135","author":"Allan JL","year":"1981","journal-title":"Eur J Pediatr"},{"key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/ajcn\/32.3.607","article-title":"Physical growth: National Center for Health Statistics percentiles","volume":"32","author":"Hamill PV","year":"1979","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_5_17_1","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/ajcn\/46.5.736","article-title":"Development of normalized curves for the international growth reference: historical and technical considerations","volume":"46","author":"Dibley MJ","year":"1987","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/ajcn\/46.5.749","article-title":"Interpretation of Z\u2010score anthropometric indicators derived from the international growth reference","volume":"46","author":"Dibley MJ","year":"1987","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_5_19_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/ppul.1950030503","article-title":"Are sex, age at diagnosis, or mode of presentation prognostic factors for cystic fibrosis","volume":"3","author":"Hudson I","year":"1987","journal-title":"Pediatr Pulmonol"},{"key":"e_1_2_5_20_1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1056\/NEJM199710023371403","article-title":"Nutritional benefits of neonatal screening for cystic fibrosis. Wisconsin Cystic Fibrosis Neonatal Screening Study Group","volume":"337","author":"Farrell PM","year":"1997","journal-title":"N Engl J Med"},{"key":"e_1_2_5_21_1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S1542-3565(04)00169-7","article-title":"Distal intestinal obstruction syndrome in adults with cystic fibrosis","volume":"2","author":"Dray X","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"e_1_2_5_22_1","first-page":"245","article-title":"Cystic fibrosis patients bearing both the common missense mutation Gly\u2010\u2010Asp at codon 551 and the delta F508 mutation are clinically indistinguishable from delta F508 homozygotes, except for decreased risk of meconium ileus","volume":"51","author":"Hamosh A","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_23_1","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1056\/NEJM199310283291804","article-title":"The Cystic Fibrosis Genotype\u2010Phenotype Consortium","volume":"329","author":"Correlation between genotype and phenotype in patients with cystic fibrosis.","year":"1993","journal-title":"N Engl J Med"},{"key":"e_1_2_5_24_1","first-page":"951","article-title":"Screening for five mutations detects 97% of cystic fibrosis (CF) chromosomes and predicts a carrier frequency of 1:29 in the Jewish Ashkenazi population","volume":"51","author":"Abeliovich D","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_25_1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/9635","article-title":"Detection of a cystic fibrosis modifier locus for meconium ileus on human chromosome 19q13","volume":"22","author":"Zielenski J","year":"1999","journal-title":"Nat Genet"},{"key":"e_1_2_5_26_1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/archsurg.1989.01410070095019","article-title":"Changing patterns of treatment and survival in neonates with meconium ileus","volume":"124","author":"Rescorla FJ","year":"1989","journal-title":"Arch Surg"},{"key":"e_1_2_5_27_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/00000658-199202000-00014","article-title":"Management and survival of meconium ileus. A 30\u2010year review","volume":"215","author":"Del Pin CA","year":"1992","journal-title":"Ann Surg"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e3181a3bfdd","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T09:17:11Z","timestamp":1707297431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e3181a3bfdd"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1097\/MPG.0b013e3181a3bfdd"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e3181a3bfdd","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}