{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:21:43Z","timestamp":1790896903862,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["OTKA K61868"],"award-info":[{"award-number":["OTKA K61868"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>We analysed whether the quantification of autoantibodies against tissue transglutaminase could be used to predict mucosal destruction and disease severity in patients with gluten sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>One hundred seventy patients with coeliac disease (CD), comprising 52 children with severe malabsorption (group I), 59 children with mild symptoms (group II), 59 adults (group III), 134 patients with dermatitis herpetiformis (DH), and 131 disease controls, were studied. Serial serum samples of patients in groups I and II on a gluten\u2010free diet were also included. Serum levels of antibodies against recombinant tissue transglutaminase were determined with ELISA using standard curves for quantification of antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Immunoglobulin (Ig)A antibodies against tissue transglutaminase (IgA\u2010TGA) were detected in all of the patients with CD and in 95% of the DH patients. The IgA\u2010TGA and IgG\u2010TGA levels were higher in group I (<jats:italic>P<\/jats:italic> &lt; 0.001). The IgG\u2010TGA levels and positivity rate in group I (100%) were higher than in group II (81%), group III (73%), and the DH group (67%). Elevated IgA\u2010TGA and IgG\u2010TGA levels in combination predicted a more severe small intestinal atrophy (<jats:italic>P<\/jats:italic> &lt; 0.0001) with a specificity of 99% for Marsh IIIb\u2013IIIc (flat) lesions. The kinetics of the IgA\u2010TGA decrease during diet differed between groups I and II.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>High levels of IgA\u2010TGA and IgG\u2010TGA antibodies were associated with the grade of mucosal villous atrophy and a more severe clinical presentation. The combined measurement of IgA\u2010TGA and IgG\u2010TGA enables a noninvasive prediction of small intestinal villous atrophy with high accuracy, and may reduce the need for a biopsy in patients with suspected CD.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181a81384","type":"journal-article","created":{"date-parts":[[2010,1,16]],"date-time":"2010-01-16T07:55:16Z","timestamp":1263628516000},"page":"140-146","source":"Crossref","is-referenced-by-count":128,"title":["Prediction of Clinical and Mucosal Severity of Coeliac Disease and Dermatitis Herpetiformis by Quantification of IgA\/IgG Serum Antibodies to Tissue Transglutaminase"],"prefix":"10.1002","volume":"50","author":[{"given":"Ingrid","family":"Dahlbom","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilma R","family":"Korponay\u2010Szab\u00f3","sequence":"additional","affiliation":[{"name":"Heim P\u00e1l Children's Hospital Department of Gastroenterology\u2010Nephrology Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit B","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Heim P\u00e1l Children's Hospital Department of Gastroenterology\u2010Nephrology Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Szalai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"M\u00e4ki","sequence":"additional","affiliation":[{"name":"Paediatric Research Centre Tampere University Hospital and University of Tampere Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Hansson","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071600"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021687"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200109000-00018"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2002.810219.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.8.909"},{"key":"e_1_2_6_7_1","first-page":"1123","article-title":"When is a coeliac a coeliac. 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A sensitive, cost\u2010effective assay for the screening of celiac disease","volume":"35","author":"Bilbao JR","year":"2002","journal-title":"Autoimmunity"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.59.6.517"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)93029-O"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.07.014"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000026296.02308.00"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200501000-00017"},{"key":"e_1_2_6_20_1","first-page":"254","article-title":"Immunoglobulin G (IgG) anti\u2010tissue transglutaminase antibodies used as markers for IgA\u2010deficient celiac disease patients","volume":"12","author":"Dahlbom I","year":"2005","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70008-3"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.50.5.357"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91819-P"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2003.tb07961.x"},{"key":"e_1_2_6_25_1","first-page":"197","article-title":"Celiac disease serology in dermatitis herpetiformis. 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