{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:42:06Z","timestamp":1791196926698,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective:<\/jats:title>\n                    <jats:p>The increasing use of sonography has resulted in an increase in the proportion of children with gallstones who are asymptomatic at the time of diagnosis. In adults, the literature supports expectant management of clinically silent gallstones. The evidence for this management approach in children is limited to a number of small series. Our objective was to review the risk factors, complications, and outcomes of gallstones at our institution, particularly in those patients who are asymptomatic at the time of initial diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      We reviewed 382 cases of gallstones in children. These patients were diagnosed with sonography. Data on age at diagnosis, presentation, sonographic findings, risk factors, complications, surgery, and follow\u2010up were collected. A\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      test was used to compare the complication rates between symptomatic and asymptomatic groups. Descriptive statistics were used to analyze the sample.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At diagnosis, 50.5% of children were asymptomatic; these patients were diagnosed at a mean age of 8.23 years. Compared with symptomatic patients, they were less likely to have a hemolytic anemia but more likely to have other risk factors, including cardiac surgery, leukemia and lymphoma, short bowel syndrome, or exposure to total parenteral nutrition or cephalosporins. These patients had a lower rate of complications than the symptomatic patients (4.6% vs 28.2% of symptomatic,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001) and only 3.1% developed symptoms that necessitated surgery (vs 59.0% of symptomatic). Of the 58 (15.1%) diagnosed in infancy, 47 (81.0%) were asymptomatic. The infant group also had low rates of complications (8.6%) and cholecystectomy (1.7%). In cases with sonographic follow\u2010up, resolution of gallstones was demonstrated in 16.5% of asymptomatic patients and in 34.1% of infants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The data suggest that clinically silent gallstones in children and infants are associated with low rates of complications and can be managed conservatively, unless complications occur. Patients with sickle cell disease, spherocytosis, and elliptocytosis had high complication rates and required surgery more often.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181b99c72","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T01:43:05Z","timestamp":1267062185000},"page":"303-308","source":"Crossref","is-referenced-by-count":106,"title":["Risk Factors, Complications, and Outcomes of Gallstones in Children: A Single\u2010center Review"],"prefix":"10.1002","volume":"50","author":[{"given":"Conor O","family":"Bogue","sequence":"first","affiliation":[{"name":"Department of Diagnostic Imaging Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Pediatric Laboratory Medicine Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Ted","family":"Gerstle","sequence":"additional","affiliation":[{"name":"Division of General and Thoracic Surgery The Hospital for Sick Children Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahim","family":"Moineddin","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Daneman","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01076936"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-199706000-00017"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(89)90199-2"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.11.9.268"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1991.02160010111028"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1622.2000.01783.x"},{"key":"e_1_2_5_8_1","first-page":"249","article-title":"Ten year incidence and natural history of gallstone disease in a rural population of women in central Italy. 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