{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T03:17:19Z","timestamp":1771039039002,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UO1DK067767\u201001"],"award-info":[{"award-number":["UO1DK067767\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 RR 025005"],"award-info":[{"award-number":["UL1 RR 025005"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MO1 RR00069"],"award-info":[{"award-number":["MO1 RR00069"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>Interferon treatment for chronic viral hepatitis C (HCV) has been associated with the development of retinopathy in 19% to 29% of adults. Our purpose is to describe the ophthalmologic complications of pegylated interferon\u2010\u03b12a with either placebo or ribavirin in children with chronic HCV (the PEDS\u2010C trial).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>Prospective, comprehensive ophthalmologic examinations including slit lamp at enrollment and after 24 and 48 weeks of treatment of 114 children participating in a randomized clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>One hundred and twenty\u2010eight children were screened for entry, of whom 123 had an eye examination and no child had existing retinal disease. One hundred fourteen children were eligible and were treated. One hundred ten children had an eye examination at 24 weeks and 103 children at 48 weeks. Three of 114 subjects (2.6%) developed documented (n = 2) or possible (1) serious eye complications. One subject developed evidence of ischemic retinopathy (cotton\u2010wool spots) by week 24, 1 developed uveitis by week 48, and 1 reported at week 48 transient (&lt;4 hours) monocular blindness that had occurred at week 36 with a subsequent normal examination at week 48.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Ophthalmologic complications are infrequent in children who are treated with pegylated interferon\u2010\u03b12a for HCV (2%\u20133%). Because of the potential severity of ischemic retinopathy and uveitis, prospective ocular assessment should remain part of the monitoring strategy for children who are treated with interferon for HCV.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181b99cf0","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T05:30:13Z","timestamp":1274938213000},"page":"183-186","source":"Crossref","is-referenced-by-count":27,"title":["Ophthalmologic Complications in Children With Chronic Hepatitis C Treated With Pegylated Interferon"],"prefix":"10.1002","volume":"51","author":[{"given":"Michael R","family":"Narkewicz","sequence":"first","affiliation":[{"name":"Departments of Pediatrics Section of Pediatric Gastroenterology, Hepatology, and Nutrition University of Colorado Denver School of Medicine and the Children's Hospital Aurora 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