{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T21:27:16Z","timestamp":1764019636183},"reference-count":82,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>The objective of the study was to ascertain the appropriateness of indications for upper gastrointestinal (UGI) endoscopy in children with dyspepsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We used the RAND\/University of California at Los Angeles method to investigate the appropriateness of the opinions of a panel of experts. The panel judged 2304 theoretical patient scenarios defined by a combination of demographic and clinical variables. Descriptive and multivariate logistic regression analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The panel rated UGI endoscopy as appropriate in 27.2% of cases, inappropriate in 14.3%, and dubious in 58.5%. Disagreement emerged for 21% of cases. UGI endoscopy was considered increasingly appropriate in cases with a positive family history of peptic ulcer and\/or <jats:italic>Helicobacter pylori<\/jats:italic> infection (odds ratio [OR] 8.518, <jats:italic>P<\/jats:italic> &lt; 0.0001), when dyspepsia interfered with activities of daily living (\u201csleep\u201d OR 7.540, <jats:italic>P<\/jats:italic> &lt; 0.0001; \u201cnormal activities\u201d OR 5.725, <jats:italic>P<\/jats:italic> &lt; 0.0001), and when patients were older than 10 years (\u201c\u226410 years\u201d OR 0.310, <jats:italic>P<\/jats:italic> &lt; 0.0001) the longer the duration (\u201c0\u20132 months\u201d OR 0.002, <jats:italic>P<\/jats:italic> &lt; 0.0001; \u201c3\u20135 months\u201d OR 0.059, <jats:italic>P<\/jats:italic> &lt; 0.0001; \u201c6\u201311 months\u201d OR 0.516, <jats:italic>P<\/jats:italic> = 0.0005) and the greater the severity (\u201cmild\u201d OR 0.002, <jats:italic>P<\/jats:italic> &lt; 0.0001; \u201cmoderate\u201d OR 0.013, <jats:italic>P<\/jats:italic> &lt; 0.0001) of their dyspeptic symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>UGI endoscopy is not appropriate for all children with dyspeptic symptoms, but only for cases with a family history of peptic ulcer and\/or <jats:italic>Helicobacter pylori<\/jats:italic> infection, older than 10 years of age, with symptoms persisting for more than 6 months and severe enough to affect activities of daily living.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181bb3362","type":"journal-article","created":{"date-parts":[[2010,3,25]],"date-time":"2010-03-25T06:29:50Z","timestamp":1269498590000},"page":"493-499","source":"Crossref","is-referenced-by-count":18,"title":["Indications to Upper Gastrointestinal Endoscopy in Children With Dyspepsia"],"prefix":"10.1002","volume":"50","author":[{"given":"G","family":"Guariso","sequence":"first","affiliation":[{"name":"Gastroenterology and Endoscopy Unit 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