{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:43:51Z","timestamp":1787010231161,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Alagille syndrome is a multisystem disorder in which progressive liver disease with persistent cholestasis and dramatic pruritus often warrant consideration for liver transplantation. The most important part of the transplant assessment is evaluation of the cardiac and renal involvement. Preoperatively, cardiac performance often must be tested with dynamic stress tests, mimicking hemodynamic changes during liver transplant. Many aspects of the syndrome including cholestasis, pruritus, and hypercholesterolemia improve posttransplant, but short stature is rarely significantly affected. One\u2010 and 5\u2010year patient and graft survival after liver transplant is comparable to other elective indications, but effects of long\u2010term immunosuppressants on evolution of other components of the syndrome, including vascular, bone, and renal disease, remain largely unknown.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181c1601f","type":"journal-article","created":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T10:25:16Z","timestamp":1261045516000},"page":"11-15","source":"Crossref","is-referenced-by-count":84,"title":["Alagille Syndrome and Liver Transplantation"],"prefix":"10.1002","volume":"50","author":[{"given":"Binita M","family":"Kamath","sequence":"first","affiliation":[{"name":"Department of Pediatrics The Children's Hospital of Philadelphia Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen B","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Pediatric Liver Center Division of Pediatric Gastroenterology and Nutrition Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nedim","family":"Had\u017ei\u0107","sequence":"additional","affiliation":[{"name":"Department of Child Health and Institute for Liver Studies King's College Medical School at King's College Hospital London 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