{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:15:51Z","timestamp":1762521351035},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R21 DK68371","U01 DK062456"],"award-info":[{"award-number":["R21 DK68371","U01 DK062456"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Biliary atresia (BA) is the most serious liver disease in infants. Diagnosis currently depends on surgical exploration of the biliary tree. Noninvasive tests that distinguish BA from other types of neonatal liver disease are not available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>To identify potential serum biomarkers that classify children with neonatal cholestasis, we performed 2\u2010dimensional difference gel electrophoresis, statistical analysis, and tandem mass spectrometry using serum samples from 19 infants with BA and 19 infants with non\u2010BA neonatal cholestasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Eleven potential serum biomarkers were found that could in combination classify children with neonatal cholestasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Although no single biomarker or imaging test adequately distinguishes BA from other types of neonatal cholestasis, combinations of biomarkers, imaging tests, and noninvasive clinical criteria should be further explored as potential tests for rapid and accurate diagnosis of BA.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181cb42ee","type":"journal-article","created":{"date-parts":[[2010,3,19]],"date-time":"2010-03-19T08:44:58Z","timestamp":1268988298000},"page":"411-416","source":"Crossref","is-referenced-by-count":14,"title":["Serum Markers May Distinguish Biliary Atresia From Other Forms of Neonatal Cholestasis"],"prefix":"10.1002","volume":"50","author":[{"given":"Hongtao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics Developmental Biology USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James P","family":"Malone","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cell Biology and Physiology Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra Erdmann","family":"Gilmore","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cell Biology and Physiology Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan E","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cell Biology and Physiology Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C","family":"Magee","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Michigan Medical School Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R Reid","family":"Townsend","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cell Biology and Physiology Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert O","family":"Heuckeroth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Developmental Biology USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2223\/JPED.1608","article-title":"Extrahepatic biliary atresia: current concepts and future directions","volume":"83","author":"Carvalho E","year":"2007","journal-title":"J Pediatr (Rio J)"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181646730"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2003.tb08098.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21790"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2709"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","unstructured":"ChakravartiB GallagherSR ChakravartiDN. 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