{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:27:04Z","timestamp":1762176424341},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>Eosinophilic oesophagitis (EE) is a clinical entity characterised by a set of symptoms and eosinophilic infiltration of the oesophageal epithelium. Recent reports indicate that EE is increasingly diagnosed in paediatric patients. We aimed to evaluate the epidemiology of paediatric EE in a European population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p>Infants and children in the Region of Southern Denmark were prospectively referred for further evaluation of symptoms of gastroesophageal reflux disease (GERD) after treatment failure with a proton pump inhibitor. The evaluation included endoscopy, 24\u2010hour oesophageal pH\u2010metry, histology of oesophageal biopsies, and investigations for food allergy (double\u2010blind, placebo\u2010controlled food challenge, skin prick test, S\u2010IgE antibodies, atopy patch test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Of the 78 referred patients, 28 qualified for a diagnosis of GERD. Six children had &gt;15 eosinophils per high\u2010power field in biopsies from the oesophageal mucosa and qualified for the diagnosis of EE. The median age at diagnosis was 9.6 years. In 4 of the 6 patients, food allergy was confirmed by double\u2010blind, placebo\u2010controlled food challenge. In the Region of Southern Denmark with a paediatric population of 256,164 between 0 and 16 years of age, a yearly incidence of EE of 0.16\/10,000 was estimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>We report a European prospective study of EE. It was documented in 6 of 78 patients with symptoms of GERD corresponding to an annual incidence of 0.16\/10,000 infants and children.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181d1b107","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T09:30:13Z","timestamp":1274952613000},"page":"280-282","source":"Crossref","is-referenced-by-count":49,"title":["Eosinophilic Oesophagitis in Infants and Children in the Region of Southern Denmark: A Prospective Study of Prevalence and Clinical Presentation"],"prefix":"10.1002","volume":"51","author":[{"given":"Kasper","family":"Dalby","sequence":"first","affiliation":[{"name":"Hans Christian Andersen Children's Hospital Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasmus G","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children's Hospital Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soren","family":"Kruse\u2010Andersen","sequence":"additional","affiliation":[{"name":"Gastrointestinal Motility Laboratory Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Fenger","sequence":"additional","affiliation":[{"name":"Department of Pathology Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Bindslev\u2010Jensen","sequence":"additional","affiliation":[{"name":"Allergy Center Odense University Hospital and University of Southern Denmark Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Ljungberg","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Esbjerg Hospital Esbjerg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Sonderborg Hospital Sonderborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Mette","family":"Walsted","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Kolding Hospital Kolding Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Husby","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children's Hospital Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200408263510924"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.100974"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.107714"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07390.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.05.026"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-005-0061-5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.121458"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61151-9"},{"key":"e_1_2_6_10_1","unstructured":"Danmarks Statistik.www.statistikbanken.dk\/BEF1A. 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