{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:21:25Z","timestamp":1788308485740,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>Gastroesophageal reflux disease (GERD) is a well\u2010recognized consequence of congenital diaphragmatic hernia (CDH). Results of studies examining predictive factors for early and late GERD are inconclusive. The aim of this study was to assess the incidence of early (&lt;2 years) and late GERD (\u22656 years) following CDH repair and to identify predictive variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>Of 183 patients born with high\u2010risk CDH, 107 survived and 38 were excluded. Perinatal and postnatal data of 69 eligible patients were analysed to identify variables predictive for early GERD. For the follow\u2010up study, 58 patients (84%) (ages 12.1 \u00b1 3.4 years; range 6\u201317) completed a standardised questionnaire. Results were compared with those from a healthy control group (n = 83). Patients who had a score indicating increased risk of GERD underwent further diagnostic assessment. Predictive factors for early and late GERD were identified using multivariate regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Early GERD was demonstrated in 27 patients (39%). Patch closure and intrathoracic position of the stomach were independent predictive variables for early GERD. At the time of follow\u2010up, 9 of 58 patients (16%) had symptoms suggestive of GERD. In 7 patients (12%), late GERD was confirmed. For late GERD, however, no perinatal or postnatal risk factors were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Early GERD is more common in CDH patients with patch closure or intrathoracic position of the stomach. Predictive factors for late GERD could not be identified and screening for early GERD does not protect for future GERD; therefore, long\u2010term follow\u2010up for GERD in CDH survivors is mandatory.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181d1b149","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T09:30:13Z","timestamp":1274952613000},"page":"448-453","source":"Crossref","is-referenced-by-count":55,"title":["Congenital Diaphragmatic Hernia: Long\u2010term Risk of Gastroesophageal Reflux Disease"],"prefix":"10.1002","volume":"51","author":[{"given":"Marieke G","family":"Peetsold","sequence":"first","affiliation":[{"name":"Department of Paediatrics VU University Medical Centre The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CM Frank","family":"Kneepkens","sequence":"additional","affiliation":[{"name":"Department of Paediatrics VU University Medical Centre The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo A","family":"Heij","sequence":"additional","affiliation":[{"name":"Paediatric Surgical Centre of Amsterdam VU University Medical Centre and Emma Children's Hospital\/AMC Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke","family":"IJsselstijn","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Erasmus Medical Centre\/Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Tibboel","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Erasmus Medical Centre\/Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinoud JBJ","family":"Gemke","sequence":"additional","affiliation":[{"name":"Department of Paediatrics VU University Medical Centre The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(05)80353-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(94)90819-2"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(09)90013-0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1072391"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(94)90141-4"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90494-7"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.04.026"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.36693"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90497-2"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.25746"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04278-9"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9738-y"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(02)00454-7"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90162-X"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1994.tb11206.x"},{"key":"e_1_2_5_17_1","volume-title":"Practical Statistics for Medical Research","author":"Altman DG","year":"1997"},{"key":"e_1_2_5_18_1","first-page":"1","article-title":"Growth diagrams 1980. 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