{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:26:34Z","timestamp":1788877594699,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim:<\/jats:title><jats:p>We investigated the impact of laparoscopic anterior hemifundoplication on gastric emptying (GE) and specific symptoms in children with and children without neurodevelopmental delays gastroesophageal reflux. Scintigraphic and ultrasonographic GE measurements were correlated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>Twenty\u2010six children (mean age 7 \u00b1 6.1 years), of whom 14 were neurodevelopmentally delayed, were evaluated prospectively before 3 and 6 months after laparoscopic anterior hemifundoplication. All of the patients underwent clinical assessments, interviews, and 24\u2010hour pH monitoring. Key symptoms were evaluated using a 5\u2010point Likert scale. Gastric emptying was assessed by Tc\u201099m\u2010DTPA\u2010scintigraphy and ultrasonography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>All of the children had significant catch\u2010up growth after fundoplication, which was more pronounced in the neurologically normal children (<jats:italic>P<\/jats:italic> &lt; 0.05 vs impaired), in line with a decrease in the use of omeprazol (mean 0.93 \u00b1 0.7 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup> \u00b7 day<jats:sup>\u22121<\/jats:sup> before and 0.06 \u00b1 0.18 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup> \u00b7 day<jats:sup>\u22121<\/jats:sup> at 6 months after operation; <jats:italic>P<\/jats:italic> &lt; 0.001). The 24\u2010hour pH monitoring normalized in all of the children, and the mean severity of the key symptoms such as vomiting, choking, and pain was significantly reduced (<jats:italic>P<\/jats:italic> &lt; 0.001). Scintigraphic GE parameters, such as the elimination rate\/minute, gastric half\u2010emptying time (t<jats:sub>1\/2<\/jats:sub>), gastric residual activity (RA), and duration of the initial merging time, were not altered significantly by the operation (<jats:italic>P<\/jats:italic> &gt; 0.05). Ultrasonographic evaluations confirmed these results [positive correlation with scintigraphy for t<jats:sub>1\/2<\/jats:sub> (<jats:italic>P<\/jats:italic> = 0.006) and RA (<jats:italic>P<\/jats:italic> = 0.01)]. The symptoms evolution and GE were uncorrelated (<jats:italic>P<\/jats:italic> &gt; 0.01). There were no significant differences between children with and children without neurodevelopmental delays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Laparoscopic anterior hemifundoplication achieves an excellent symptomatic outcome without affecting GE in children with and children without neurodevelopmental delays.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181d1f1c8","type":"journal-article","created":{"date-parts":[[2010,6,5]],"date-time":"2010-06-05T07:38:27Z","timestamp":1275723507000},"page":"437-442","source":"Crossref","is-referenced-by-count":10,"title":["Laparoscopic Anterior Hemifundoplication Improves Key Symptoms Without Impact on GE in Children With and Children Without Neurodevelopmental Delays"],"prefix":"10.1002","volume":"51","author":[{"given":"Carsten","family":"Engelmann","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Gritsa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus F","family":"Gratz","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Hannover Medical School Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benno M","family":"Ure","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200401000-00001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000210500.64440.76"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80633-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-005-0033-x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.5.661"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(97)90075-1"},{"key":"e_1_2_7_8_1","first-page":"907","article-title":"Nissen fundopliction improves gastric motiliy in patients with delayed gastric emptying","volume":"20","author":"Farrel TM","year":"1999","journal-title":"Nucl Med Commun"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5465"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(83)90155-5"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00188523"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2005.tb01183.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2004.10.023"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800820229"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-965393"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199205000-00017"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199705000-00004"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70155-6"},{"key":"e_1_2_7_19_1","first-page":"267","article-title":"Gastric emptying of liquid meals. 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