{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:27:56Z","timestamp":1790447276504,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Biliary atresia (BA) is a leading cause of end\u2010stage paediatric liver disease. Standard BA treatment is sequential surgery with an initial Kasai procedure (KP) followed by liver transplant (LT) for patients who progress to liver failure. A key determinant for the post\u2010KP patient survival with their native liver is patient age at KP (older age, poorer outcome). Recently, European studies have reported that caseload experience influences prognosis with centres managing &lt;5 cases per year (UK) or &lt;2 cases per year (France) having worse survival. Our study investigates the effect of caseload experience on outcomes of Canadian patients with BA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>A national database of cases with BA, born from 1992 to 2002, was examined. Patients were grouped according to treatment centre size (A: on average &lt;1 case per year; B: 1 to 3 cases per year; and C: &gt;3 cases per year). Overall patient, post\u2010KP native liver, and LT survivals were compared between centres. Outcome parameters were reevaluated for patients grouped by the largest Canadian centre (&gt;5 cases per year) and all other centres (&lt;5 cases per year).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Two\u2010hundred thirty patients were identified among 6 group A, 4 group B, and 2 group C centres. The overall median age at KP was 64 days. There were no significant differences in patient, post\u2010KP native liver, or LT survivals between the sized centres and even the largest centre, with the overall 4\u2010year post\u2010KP native liver survival being 39%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Caseload experience does not importantly affect the outcomes for Canadian children with BA. Although outcomes in Canada are comparable to those elsewhere, national policies directed towards timely referral and earlier age at KP rather than centralisation of care are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181d67e5e","type":"journal-article","created":{"date-parts":[[2010,6,11]],"date-time":"2010-06-11T11:27:08Z","timestamp":1276255628000},"page":"61-65","source":"Crossref","is-referenced-by-count":45,"title":["Biliary Atresia in Canada: The Effect of Centre Caseload Experience on Outcome"],"prefix":"10.1002","volume":"51","author":[{"given":"Richard A","family":"Schreiber","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Pediatrics Faculty of Medicine University of British Columbia Vancouver BC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collin C","family":"Barker","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Pediatrics Faculty of Medicine University of British Columbia Vancouver BC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve A","family":"Roberts","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Departments of Pediatrics, Medicine and Pharmacology Faculty of Medicine University of Toronto Toronto Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R","family":"Martin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Hepatology and Nutrition Department of Pediatrics Faculty of Medicine Universite de Montreal Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Canadian Pediatric Hepatology Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230652"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2005.10.001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2002.tb07741.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300330"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)03492-3"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(03)00178-7"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1038479"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.05.051"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1949"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2003.50069"},{"key":"e_1_2_5_12_1","unstructured":"A randomized double\u2010blinded placebo\u2010controlled trial of corticosteroid therapy following portoenterostomy.http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00294684?term=biliary+atresia+and+US&rank=2. Accessed June 22 2009."},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16045-5"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21219"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.03.007"},{"key":"e_1_2_5_16_1","unstructured":"OngE SharifK AlizaiN KellyD McCleanP DavenportM.Biliary atresia in the 21st century\u2010\u2010the centralization experience. Paper presented at the British Association of Paediatric Surgeons meeting June 17\u201020 2009 Graz Austria."},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.12.054"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03404348"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22182"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e3181d67e5e","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T08:30:32Z","timestamp":1705566632000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e3181d67e5e"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1097\/MPG.0b013e3181d67e5e"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e3181d67e5e","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.3906956.3653054","asserted-by":"object"}]},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}