{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:20:30Z","timestamp":1788222030362,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim:<\/jats:title><jats:p>Some patients with eosinophilic esophagitis (EE) (&gt;15 eosinophils\/high\u2010power field on esophageal mucosal biopsies and lack of response to acid suppression and\/or normal pH probe study) demonstrate incidental eosinophilic inflammation of the gastric mucosa. It is unclear whether patients with EE and normal gastric biopsies (EE\u2010N) are phenotypically different from patients with EE and gastric mucosal abnormalities (EE\u2010A) (ie, &gt;10 eos\/hpf on gastric biopsies). The aim of the study was to compare the clinical features and response to therapy among patients with EE\u2010N and EE\u2010A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>Medical records of all of the EE\u2010A and a random group of patients with EE\u2010N diagnosed during an 8\u2010year period were reviewed. A subgroup analysis of patients treated with swallowed fluticasone with a repeat esophagogastroduodenoscopy within 6 months of starting therapy was also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>During the study period, 41 patients had EE\u2010A. When compared to 50 random patients with EE\u2010N, no clinical differences were noted, including sex, age, presenting symptoms, esophageal histology, and atopy history. Eleven (27%) of the 41 EE\u2010A and 14 (28%) of the 50 EE\u2010N patients were treated with swallowed fluticasone, and the response was similar among the groups. The mean esophageal eosinophils\/high\u2010power field among the EE\u2010A group dropped from 47 to 8 compared with a 46 to 7 drop among the EE\u2010N group treated with fluticasone therapy (<jats:italic>P<\/jats:italic> = 0.91). In 9 (82%) of the 11 patients with EE\u2010A treated with fluticasone, there was resolution (7 of 9) or significant improvement (2 of 9) of gastric eosinophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Patients with EE\u2010A and EE\u2010N have similar clinical presentations. Incidental gastric inflammation does not predict a worse response of esophageal inflammation to fluticasone and should not exclude its use in patients with EE\u2010A. In fact, gastric inflammation responded to swallowed fluticasone in the majority of patients with EE\u2010A. This observation should foster further investigation into pathogenesis of EE and presumed esophagogastric inflammatory axis.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181d98e6c","type":"journal-article","created":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T07:36:11Z","timestamp":1277969771000},"page":"723-726","source":"Crossref","is-referenced-by-count":21,"title":["Incidental Gastric Eosinophils in Patients With Eosinophilic Esophagitis: Do They Matter?"],"prefix":"10.1002","volume":"51","author":[{"given":"Rana F","family":"Ammoury","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Indiana University School of Medicine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc B","family":"Rosenman","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Indiana University School of Medicine Indianapolis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donita","family":"Roettcher","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Indiana University School of Medicine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep K","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Indiana University School of Medicine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.017"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31806210c8"},{"key":"e_1_2_6_4_1","first-page":"110","article-title":"A quantitative evaluation of mucosal eosinophils in the pediatric gastrointestinal tract","volume":"9","author":"Lowichik 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