{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:11:56Z","timestamp":1754107916491},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:sec><jats:title>Background and Aim:<\/jats:title><jats:p>Low bone mineral density (BMD) has recently been recognized as a potential health problem in children with inflammatory bowel disease (IBD). Our aim was to investigate the familial resemblance of BMD in pediatric patients with IBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>In this population\u2010based study from western Sweden, we assessed 144 children with IBD, 83 with ulcerative colitis, 45 with Crohn disease, 16 with indeterminate colitis, and their parents (136 mothers and 130 fathers) with dual\u2010energy X\u2010ray absorptiometry (DEXA). After adjustment for sex, age, weight, height, and parental IBD, we correlated the BMD of the patients to the BMD of their mothers, fathers, and the midparent value ([mother's BMD + father's BMD]\/2) at different skeletal sites and calculated the Pearson correlation coefficient (<jats:italic>r<\/jats:italic>) to evaluate the extent of familial resemblance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The BMD of the children with IBD was clearly related to the BMD of their parents. The strongest correlation was found in the femoral neck with <jats:italic>r<\/jats:italic> = 0.55 (<jats:italic>P<\/jats:italic> &lt; 0.001, 95% CI 0.41\u20130.66) between BMD of the children and the midparent value. The group of children with IBD had an odds ratio of 5.96 for decreased BMD (lumbar spine <jats:italic>z<\/jats:italic> score &lt; \u22121 standard deviation) given that decreased BMD was diagnosed in both parents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>We conclude that BMD in children and adolescents with IBD is significantly related to that of their parents. In a clinical setting, it may be helpful to assess the parents of children with IBD with DEXA to interpret the children's DEXA measurements.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181dbf42c","type":"journal-article","created":{"date-parts":[[2010,6,5]],"date-time":"2010-06-05T07:38:27Z","timestamp":1275723507000},"page":"146-150","source":"Crossref","is-referenced-by-count":4,"title":["Familial Resemblance of Bone Mineral Density in Children With Inflammatory Bowel Disease"],"prefix":"10.1002","volume":"51","author":[{"given":"Susanne","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Pediatrics Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Mellstr\u00f6m","sequence":"additional","affiliation":[{"name":"Section of Geriatrics Department of Public Health and Community Medicine Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ensio","family":"Norjavaara","sequence":"additional","affiliation":[{"name":"Pediatric Growth Research Center Department of Pediatrics Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valter","family":"Sundh","sequence":"additional","affiliation":[{"name":"Section of Geriatrics Department of Public Health and Community Medicine Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Saalman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70055-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.4.325"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.2.188"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70309-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000228105.91240.80"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1385\/JCD:7:3:290"},{"key":"e_1_2_7_8_1","first-page":"62","article-title":"Bone metabolism in 53 children and adolescents with chronic inflammatory bowel disease","volume":"216","author":"Scheer K","year":"2004","journal-title":"Klin Padiatr"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.3780050304"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000201152"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199703000-00011"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20039"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70058-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00866.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70362-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655202753416876"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199907000-00013"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.6.8621"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.5.644"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.18158"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.064212"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000148735.21084.D3"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04679.x"},{"key":"e_1_2_7_24_1","first-page":"54","article-title":"Osteoporosis as a pediatric disease: role of calcium and heredity","volume":"33","author":"Matkovic V","year":"1992","journal-title":"J Rheumatol Suppl"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113125"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198903023200903"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650060606"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1330265"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050226"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380110"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/44.1.99"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1985.tb02540.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MPG.0000163736.30261.82"},{"key":"e_1_2_7_34_1","unstructured":"WackerW BardenHS.Pediatric Reference Data for Male and Female Total Body and Spine BMD and BMC. 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