{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:03:49Z","timestamp":1705622629829},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>We compared sedation by propofol combined with either fentanyl or remifentanil in pediatric outpatients undergoing diagnostic esophagogastroduodenoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>Forty\u2010two children scheduled for esophagogastroduodenoscopy in our institution were randomly assigned to receive 2 mg\/kg propofol plus either 1 \u03bcg\/kg bolus of fentanyl (group F; n = 20) or 0.5 \u03bcg\/kg bolus of remifentanil (group R; n = 22). Cardiorespiratory parameters, sedation level, adverse effects related to the drugs and\/or to the procedure, ease of performance for the endoscopist, and time to awakening were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>There were no clinically significant changes in hemodynamics. Apnea periods &gt;20 seconds and decreases in SaO<jats:sub>2<\/jats:sub> &lt;90% occurred more frequently in group R (31.8% vs 0%, <jats:italic>P<\/jats:italic> &lt; 0.01, and 27.3% vs 5.0%, <jats:italic>P<\/jats:italic> &gt; 0.05, respectively). Children in group R had significantly shorter average time to awakening: 9.5 \u00b1 5.6 vs 16.5 \u00b1 10.5 minutes (<jats:italic>P<\/jats:italic> = 0.01), and received a significantly lower total dose of propofol (<jats:italic>P<\/jats:italic> = 0.034). Adverse effects within the first 24 hours postprocedure occurred less frequently in group R (<jats:italic>P<\/jats:italic> = 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Remifentanil in combination with propofol provides good analgesic and sedative effects, which were shorter lasting compared with fentanyl\u2010based sedation, and caused fewer delayed adverse effects. The use of remifentanil was associated with respiratory depression, emphasizing the need for experienced anesthesiologists.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181ddaeb3","type":"journal-article","created":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T11:40:57Z","timestamp":1283254857000},"page":"618-621","source":"Crossref","is-referenced-by-count":7,"title":["Remifentanil Versus Fentanyl for Esophagogastroduodenoscopy in Children"],"prefix":"10.1002","volume":"51","author":[{"given":"Irina","family":"Hirsh","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Critical Care and Pain Medicine Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Lerner","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Nutrition Unit Lady Davis Carmel Medical Center, and the Ruth and Bruce Rappaport Faculty of Medicine Technion\u2014Israel Institute of Technology Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilia","family":"Shnaider","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Critical Care and Pain Medicine Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Reuveni","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Critical Care and Pain Medicine Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avi","family":"Pacht","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Nutrition Unit Lady Davis Carmel Medical Center, and the Ruth and Bruce Rappaport Faculty of Medicine Technion\u2014Israel Institute of Technology Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ori","family":"Segol","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reuven","family":"Pizov","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Critical Care and Pain Medicine Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(05)80607-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0265021505001432"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200007000-00010"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2003.tb08132.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000228099.04702.39"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544080-00002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565130-00007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/81.1.51"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200207000-00012"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2008.03.006"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200005000-00003"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000134810.60270.E8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2001.00662.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200106000-00011"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200406000-00008"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-1-4020-5947-6","volume-title":"Opioids in Medicine: A Comprehensive Review on the Mode of Action and the Use of Analgesics in Different Clinical Pain States","author":"Freye E","year":"2008"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2005.00650.x"}],"container-title":["Journal of Pediatric Gastroenterology and 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