{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:39:35Z","timestamp":1761561575043},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>The extent of the digestive\/absorptive involvement in atypical presentation of celiac disease (CD) is not always clear. The aim of the study was to assess nutritional status of iron (Fe), copper (Cu), and zinc (Zn) in patients with typical CD (TCD) and atypical CD (ACD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>A cross\u2010sectional study was done in patients with TCD, ACD, and healthy controls (HC). Hemoglobin, serum ferritin, free erythrocyte protoporphyrin, Fe, Cu, ceruloplasmin, Zn, anti\u2010endomysial antibodies, and anti\u2010tissue transglutaminase antibodies were measured. Data were analyzed by Kruskal\u2010Wallis, principal component analysis, and linear discriminant analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>One hundred nine individuals were studied (54 TCD, 19 ACD, 36 HC); mean age \u00b1 standard deviation was 23 \u00b1 15.8 (range 1.6\u201375.4) years. Median and range of hemoglobin were 12.8 g\/dL (8.1\u201317.6) in TCD, 12.4 g\/dL (10.5\u201314.5) in ACD, and 13.6 g\/dL (11.1\u201316.7) in HC (<jats:italic>P<\/jats:italic> &lt; 0.0001); serum ferritin was 17.7 \u03bcg\/L (2.9\u2013157), 10.8 \u03bcg\/L (2.7\u201339.8), and 28.7 \u03bcg\/L (4.5\u2013127.2), respectively (<jats:italic>P<\/jats:italic> &lt; 0.01). Cu was 105 \u03bcg\/dL (60\u2013185), 97.5 \u03bcg\/dL (40\u2013130), and 125 \u03bcg\/dL (80\u2013205), respectively (<jats:italic>P<\/jats:italic> &lt; 0.05). Ceruloplasmin was 21.6 mg\/dL (14.2\u201373.2), 22.6 mg\/dL (0.9\u201334.3), and 32.1 mg\/dL (5.8\u201372.6), respectively (<jats:italic>P<\/jats:italic> &lt; 0.01). There were no differences in Fe, free erythrocyte protoporphyrin, and Zn. Principal component analysis showed that 58% of observed variability was explained by Fe and Cu indicators. Linear discriminant analysis revealed differences between CD and HC (<jats:italic>P<\/jats:italic> &lt; 0.0001), with high values of correct classification for TCD (73%) and HC (72%), but not ACD (16%), which were mostly classified as TCD (79%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Deficiency of micronutrients was found both in typical as well as in atypical cases.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181f988fc","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T20:46:18Z","timestamp":1317761178000},"page":"265-270","source":"Crossref","is-referenced-by-count":39,"title":["Micronutrient Deficiencies in Patients With Typical and Atypical Celiac Disease"],"prefix":"10.1002","volume":"53","author":[{"given":"Jorge E.","family":"Botero\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Institute of Nutrition and Food Technology INTA University of Chile Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Araya","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Technology INTA University of Chile Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Parada","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Technology INTA University of Chile Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco A.","family":"M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Technology INTA University of Chile Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Pizarro","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Technology INTA University of Chile Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelly","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Hospital Militar Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Canales","sequence":"additional","affiliation":[{"name":"Hospital Exequiel Gonz\u00e1lez Cort\u00e9s Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital San Juan de Dios Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.015"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2007.01.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071600"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2007.38"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31815ce5d1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32830edc1e"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2005.01.008"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.010"},{"key":"e_1_2_6_11_1","first-page":"822","article-title":"Spectrum of atypical celiac disease in north indian children","volume":"41","author":"Puri AS","year":"2004","journal-title":"Indian Pediatr"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-031104"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000325473.13088.18"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181354294"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.614"},{"key":"e_1_2_6_16_1","unstructured":"World Health Organization.The World Health Organization Child Growth Standards.http:\/\/www.who.int\/childgrowth\/en\/. 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