{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:54:43Z","timestamp":1777694083419,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32DK007477\u201025"],"award-info":[{"award-number":["T32DK007477\u201025"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24DK082792A"],"award-info":[{"award-number":["K24DK082792A"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K24HD058795"],"award-info":[{"award-number":["1K24HD058795"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objectives:<\/jats:title><jats:p>Gastrointestinal dysmotility is common in pediatric short\u2010bowel syndrome, leading to prolonged parenteral nutrition dependence. There is limited literature regarding the safety and efficacy of cisapride for this indication. The aim of the study was to describe the safety and efficacy of cisapride for enteral intolerance in pediatric short\u2010bowel syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Open\u2010labeled pilot study in a limited access program for cisapride. Indications were short\u2010bowel syndrome with underlying dysmotility and difficulty advancing enteral feeds despite standard therapies and without evidence of anatomic obstruction. Patients received cisapride 0.1 to 0.2 mg\/kg per dose for 3 to 4 doses per day. We collected electrocardiogram, nutrition, and anthropometric data prospectively at study visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Ten patients with mean (SD) age of 30.3 (30.5) months were enrolled in our multidisciplinary pediatric intestinal rehabilitation program. Median (interquartile range [IQR]) duration of follow\u2010up was 8.7 (3.1\u201314.3) months. Median (IQR) residual bowel length was 102 (85\u2013130) cm. Median (IQR) citrulline level was 14.5 (10.5\u201331.3) \u03bcmol\/L. Diagnoses included isolated gastroschisis (n = 3), gastroschisis with intestinal atresia (n = 4), necrotizing enterocolitis (n = 2), and long\u2010segment Hirschsprung disease (n = 1). Six subjects had at least 1 prior bowel\u2010lengthening procedure. Median (IQR) change in percentage enteral energy intake was 19.9% (15.4%\u201329.8%) during follow\u2010up (<jats:italic>P<\/jats:italic> = 0.01). Seven patients improved in enteral tolerance during treatment and 2 were weaned completely from parenteral nutrition. Complications during therapy were prolonged corrected QT interval (n = 2), gastrointestinal bleeding (n = 2), D\u2010lactic acidosis (n = 1), and death due to presumed sepsis (n = 1). Longitudinal analysis (general estimating equation model) showed a strong positive association between cisapride duration and improved enteral tolerance. Mean percentage of enteral intake increased by 2.9% for every month of cisapride treatment (<jats:italic>P<\/jats:italic> &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Cisapride is a potentially useful therapy in patients with pediatric short\u2010bowel syndrome with gastrointestinal dysmotility. We observed modest improvement in feeding tolerance where prior treatments failed; however, patients treated with cisapride require careful cardiac monitoring because corrected QT prolongation occurred in 20% of our cohort.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3181fe2d7a","type":"journal-article","created":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T04:49:21Z","timestamp":1301028561000},"page":"590-594","source":"Crossref","is-referenced-by-count":26,"title":["Cisapride Improves Enteral Tolerance in Pediatric Short\u2010bowel Syndrome With Dysmotility"],"prefix":"10.1002","volume":"52","author":[{"given":"Bram P","family":"Raphael","sequence":"first","affiliation":[{"name":"Center for Advanced Intestinal Rehabilitation USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Nurko","sequence":"additional","affiliation":[{"name":"Center for Motility and Functional Gastrointestinal Disorders 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