{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:35:45Z","timestamp":1790386545541,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>Gastroesophageal reflux (GER) and dismotility occur frequently after repair of esophageal atresia (EA). GER\u2010associated complications can manifest either early or later; then precocious diagnosis and treatment are essential. The aim of the study was to evaluate characteristics of GER and esophageal clearance in children treated for EA with distal tracheoesophageal fistula, using pH\u2010multichannel intraluminal impedance (pH\u2010MII).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>Twenty\u2010two children (ages 3\u201340 months) treated for EA at birth, and 20 normal children of similar age with suspected GER disease were included in the study. Impedance parameters were analyzed according to age and symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Reflux events were mainly nonacidic. About bolus exposure index, mean acid clearing time (MACT), and mean bolus clearing time (MBCT), a significant difference was found between 2 groups: the median MACT and MBCT were longer, with values of 281 and 39 seconds, respectively, in the EA group and 110 and 15 seconds in the control group (<jats:italic>P<\/jats:italic> &lt; 0.0005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Our data show that in young patients the majority of refluxes are not acid. This implies that the incidence of GER may be underestimated if pH\u2010metry is used. The pH\u2010MII is an ideal test in children because it studies both GER with its characteristics and motility pattern. The quality of reflux does not seem to influence the onset of symptoms that are related to an impaired esophageal clearance. Hence, this technique could be useful to study patients treated for EA, avoiding the onset of complications.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e318202a3e5","type":"journal-article","created":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T04:49:21Z","timestamp":1301028561000},"page":"686-690","source":"Crossref","is-referenced-by-count":37,"title":["Gastroesophageal Reflux in Young Children Treated for Esophageal Atresia: Evaluation With pH\u2010Multichannel Intraluminal Impedance"],"prefix":"10.1002","volume":"52","author":[{"given":"Pieralba","family":"Catalano","sequence":"first","affiliation":[{"name":"Pediatric Surgical Unit Department of Mother and Child Care University of Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria R","family":"Di Pace","sequence":"additional","affiliation":[{"name":"Pediatric Surgical Unit Department of Mother and Child Care University of Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M","family":"Caruso","sequence":"additional","affiliation":[{"name":"Pediatric Surgical Unit Department of Mother and Child Care University of Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Casuccio","sequence":"additional","affiliation":[{"name":"Pediatric Surgical Unit Department of Mother and Child Care University of Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"De Grazia","sequence":"additional","affiliation":[{"name":"Pediatric Surgical Unit Department of Mother and Child Care University of Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"352","volume-title":"Pediatric Surgery","author":"Spitz 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